This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SPRY2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPRY2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPRY2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:79,782,637–79,783,283 | 558.2 kb | Distal (>10kb) Multiome HiCAR | 287 | |
| chr13:79,859,849–79,860,792 | 480.7 kb | Distal (>10kb) Multiome HiCAR | 100 | |
| chr13:80,217,921–80,218,684 | 122.8 kb | Distal (>10kb) Multiome | 213 | |
| chr13:80,276,254–80,277,363 | 64.5 kb | Distal (>10kb) Multiome | 303 | |
| chr13:80,296,554–80,297,542 | 43.9 kb | Distal (>10kb) Multiome | 186 | |
| chr13:80,329,326–80,330,117 | 9.5 kb | Proximal (<10kb) | 32 | |
| chr13:80,336,999–80,337,842 | 1.8 kb | Proximal (<10kb) | 96 | |
| chr13:80,338,705–80,339,496 | 2.0 kb | Proximal (<10kb) Multiome | 472 | |
| chr13:80,339,610–80,339,768 | at TSS | At TSS | 130 | |
| chr13:80,339,903–80,342,253 | 205 bp | At TSS Multiome | 880 | |
| chr13:80,342,358–80,343,596 | 1.9 kb | Proximal (<10kb) Multiome | 668 | |
| chr13:80,344,631–80,345,447 | 5.0 kb | Proximal (<10kb) | 25 | |
| chr13:80,359,092–80,360,332 | 18.7 kb | Distal (>10kb) Multiome | 419 | |
| chr13:80,361,640–80,362,668 | 21.0 kb | Distal (>10kb) Multiome | 340 |
Genomic view of the SPRY2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.