The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for SLC16A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC16A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC16A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,674,125–112,675,737 | 280.8 kb | Distal (>10kb) Multiome | 910 | |
| chr1:112,700,203–112,701,476 | 255.4 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,704,514–112,705,591 | 251.0 kb | Distal (>10kb) Multiome | 694 | |
| chr1:112,706,536–112,707,966 | 248.9 kb | Distal (>10kb) Multiome | 784 | |
| chr1:112,714,149–112,716,774 | 239.6 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,743,679–112,744,585 | 212.0 kb | Distal (>10kb) Multiome | 198 | |
| chr1:112,790,881–112,791,569 | 164.9 kb | Distal (>10kb) Multiome | 158 | |
| chr1:112,794,180–112,795,498 | 161.1 kb | Distal (>10kb) Multiome | 251 | |
| chr1:112,809,091–112,810,187 | 146.5 kb | Distal (>10kb) Multiome | 445 | |
| chr1:112,817,716–112,818,473 | 138.1 kb | Distal (>10kb) Multiome | 249 | |
| chr1:112,819,120–112,820,730 | 136.8 kb | Distal (>10kb) Multiome | 456 | |
| chr1:112,825,474–112,826,954 | 130.3 kb | Distal (>10kb) Multiome HiCAR | 182 | |
| chr1:112,841,024–112,841,798 | 114.8 kb | Distal (>10kb) Multiome | 215 | |
| chr1:112,849,324–112,850,157 | 106.4 kb | Distal (>10kb) Multiome | 352 | |
| chr1:112,950,561–112,950,774 | 5.4 kb | Proximal (<10kb) | 17 | |
| chr1:112,955,281–112,957,849 | 135 bp | At TSS Multiome | 1108 | |
| chr1:113,040,180–113,041,009 | 84.2 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr1:113,041,702–113,043,423 | 86.6 kb | Distal (>10kb) Multiome HiCAR | 544 | |
| chr1:113,043,627–113,044,178 | 87.8 kb | Distal (>10kb) Multiome HiCAR | 105 | |
| chr1:113,072,181–113,073,766 | 116.9 kb | Distal (>10kb) Multiome | 975 | |
| chr1:113,140,616–113,141,422 | 184.8 kb | Distal (>10kb) Multiome | 413 | |
| chr1:113,217,521–113,218,452 | 261.8 kb | Distal (>10kb) Multiome | 479 | |
| chr1:113,223,494–113,224,107 | 267.6 kb | Distal (>10kb) Multiome | 75 | |
| chr1:113,234,064–113,234,645 | 278.2 kb | Distal (>10kb) Multiome | 67 | |
| chr1:113,252,166–113,252,950 | 296.2 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the SLC16A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.