Enables 3-hydroxybutyrate dehydrogenase activity and NAD binding activity. Involved in epithelial cell differentiation and fatty acid beta-oxidation. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BDH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BDH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BDH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:102,430,899–102,431,874 | 668.5 kb | Distal (>10kb) Multiome HiCAR | 452 | |
| chr4:102,826,418–102,828,875 | 271.8 kb | Distal (>10kb) Multiome | 1216 | |
| chr4:102,868,279–102,869,865 | 230.8 kb | Distal (>10kb) Multiome | 1045 | |
| chr4:103,018,881–103,020,188 | 80.2 kb | Distal (>10kb) Multiome | 882 | |
| chr4:103,075,865–103,077,254 | 23.3 kb | Distal (>10kb) Multiome | 845 | |
| chr4:103,099,200–103,100,254 | at TSS | At TSS | 371 | |
| chr4:103,197,655–103,198,939 | 98.6 kb | Distal (>10kb) Multiome | 812 |
Genomic view of the BDH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.