Predicted to enable gamma-tubulin binding activity. Predicted to be involved in microtubule nucleation and mitotic cell cycle. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NEDD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEDD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEDD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:96,906,645–96,908,185 | 76 bp | At TSS Multiome | 872 | |
| chr12:96,916,857–96,917,140 | 9.6 kb | Proximal (<10kb) | 5 | |
| chr12:96,917,256–96,917,422 | 9.8 kb | Proximal (<10kb) | 6 | |
| chr12:96,985,502–96,986,307 | 78.5 kb | Distal (>10kb) Multiome | 311 | |
| chr12:97,131,381–97,132,173 | 224.5 kb | Distal (>10kb) Multiome | 206 | |
| chr12:98,397,273–98,398,042 | 1490.4 kb | Distal (>10kb) Multiome HiCAR | 455 |
Genomic view of the NEDD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.