GSN
gelsolin | DKFZp313L0718

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Member of: DE-7 DE-7.5 Developmental clusters: GC7
Biological processes 80 terms
actin binding (GO:0003779)actin cap (GO:0030478)actin cytoskeleton (GO:0015629)actin cytoskeleton (GO:0015629)actin cytoskeleton (GO:0015629)actin cytoskeleton organization (GO:0030036)actin filament binding (GO:0051015)actin filament binding (GO:0051015)actin filament capping (GO:0051693)actin filament capping (GO:0051693)actin filament capping (GO:0051693)actin filament depolymerization (GO:0030042)actin filament depolymerization (GO:0030042)actin filament organization (GO:0007015)actin filament polymerization (GO:0030041)actin filament polymerization (GO:0030041)actin filament polymerization (GO:0030041)actin filament severing (GO:0051014)actin filament severing (GO:0051014)actin filament severing (GO:0051014)actin filament severing (GO:0051014)actin polymerization or depolymerization (GO:0008154)amyloid fibril formation (GO:1990000)barbed-end actin filament capping (GO:0051016)barbed-end actin filament capping (GO:0051016)blood microparticle (GO:0072562)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)cardiac muscle cell contraction (GO:0086003)cardiac muscle cell contraction (GO:0086003)cell projection assembly (GO:0030031)central nervous system development (GO:0007417)cilium assembly (GO:0060271)cortical actin cytoskeleton (GO:0030864)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)focal adhesion (GO:0005925)focal adhesion (GO:0005925)hepatocyte apoptotic process (GO:0097284)host-mediated suppression of symbiont invasion (GO:0046597)lamellipodium (GO:0030027)myosin II binding (GO:0045159)nucleus (GO:0005634)phagocytic vesicle (GO:0045335)phagocytosis, engulfment (GO:0006911)phagocytosis, engulfment (GO:0006911)phosphatidylinositol 3-kinase catalytic subunit binding (GO:0036313)phosphatidylinositol 3-kinase catalytic subunit binding (GO:0036313)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)plasma membrane (GO:0005886)positive regulation of actin nucleation (GO:0051127)positive regulation of actin nucleation (GO:0051127)positive regulation of apoptotic process (GO:0043065)positive regulation of gene expression (GO:0010628)positive regulation of keratinocyte apoptotic process (GO:1902174)positive regulation of protein processing in phagocytic vesicle (GO:1903923)positive regulation of protein processing in phagocytic vesicle (GO:1903923)protein binding (GO:0005515)protein destabilization (GO:0031648)regulation of establishment of T cell polarity (GO:1903903)regulation of plasma membrane raft polarization (GO:1903906)regulation of receptor clustering (GO:1903909)relaxation of cardiac muscle (GO:0055119)relaxation of cardiac muscle (GO:0055119)renal protein absorption (GO:0097017)response to muscle stretch (GO:0035994)response to muscle stretch (GO:0035994)sarcoplasm (GO:0016528)secretory granule lumen (GO:0034774)striated muscle atrophy (GO:0014891)
Expression (TPM)
GSN — as a Regulated Gene

TFs regulating GSN 0 TFs

Transcription factors with Perturb-seq knockdown data for GSN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GSN

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr9:121,074,349–121,075,511 193.2 kb Distal (>10kb) Multiome 1041
chr9:121,121,551–121,122,082 146.4 kb Distal (>10kb) Multiome 539
chr9:121,201,011–121,202,492 66.2 kb Distal (>10kb) Multiome 850
chr9:121,221,026–121,221,471 46.9 kb Distal (>10kb) Multiome 78
chr9:121,267,686–121,269,264 86 bp At TSS Multiome 550
chr9:121,286,406–121,287,700 19.2 kb Distal (>10kb) Multiome 735
chr9:121,299,542–121,300,058 31.6 kb Distal (>10kb) Multiome 428
chr9:121,369,661–121,370,788 102.2 kb Distal (>10kb) Multiome 849
chr9:121,499,468–121,500,318 231.8 kb Distal (>10kb) Multiome 361
chr9:121,545,736–121,546,521 278.0 kb Distal (>10kb) Multiome 559
chr9:121,550,534–121,551,203 282.6 kb Distal (>10kb) Multiome 479

Genome Browser

Genomic view of the GSN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr9:121,064,349 – 121,561,203
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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