Predicted to be involved in several processes, including hematopoietic stem cell homeostasis; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of stem cell differentiation. Located in membrane and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OCIAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OCIAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OCIAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:48,672,488–48,674,017 | 157.9 kb | Distal (>10kb) Multiome | 47 | |
| chr4:48,779,153–48,781,129 | 50.7 kb | Distal (>10kb) Multiome | 820 | |
| chr4:48,830,446–48,831,681 | 11 bp | At TSS Multiome | 800 | |
| chr4:48,906,159–48,907,243 | 75.7 kb | Distal (>10kb) Multiome | 490 | |
| chr4:48,914,069–48,914,976 | 83.4 kb | Distal (>10kb) Multiome | 105 | |
| chr4:48,985,704–48,986,746 | 155.1 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the OCIAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.