EPN1

epsin 1

This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]

Member of: DE-7 DE-7.8 Developmental clusters: GC7

Biological processes 17 terms

clathrin binding (GO:0030276)clathrin vesicle coat (GO:0030125)clathrin-coated pit (GO:0005905)cytoplasm (GO:0005737)cytosol (GO:0005829)endocytosis (GO:0006897)endocytosis (GO:0006897)endosome (GO:0005768)molecular sequestering activity (GO:0140313)molecular sequestering activity (GO:0140313)negative regulation of sprouting angiogenesis (GO:1903671)nucleus (GO:0005634)phospholipid binding (GO:0005543)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)

Expression (TPM)

TFs regulating EPN1 0 TFs

Transcription factors with Perturb-seq knockdown data for EPN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to EPN1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:55,080,038–55,082,744	594.9 kb	Distal (>10kb) Multiome HiCAR	639
chr19:55,383,539–55,384,553	291.3 kb	Distal (>10kb) Multiome	374
chr19:55,384,697–55,386,560	289.5 kb	Distal (>10kb) Multiome	903
chr19:55,406,950–55,408,675	267.2 kb	Distal (>10kb) Multiome	965
chr19:55,452,738–55,453,308	222.1 kb	Distal (>10kb) Multiome	339
chr19:55,460,784–55,462,230	213.4 kb	Distal (>10kb) Multiome	947
chr19:55,476,048–55,477,307	198.5 kb	Distal (>10kb) Multiome	1007
chr19:55,484,846–55,485,682	190.1 kb	Distal (>10kb) Multiome	594
chr19:55,503,638–55,504,310	171.2 kb	Distal (>10kb) Multiome	710
chr19:55,516,768–55,517,459	158.1 kb	Distal (>10kb) Multiome	583
chr19:55,536,923–55,537,366	138.0 kb	Distal (>10kb) Multiome	180
chr19:55,549,822–55,550,343	125.2 kb	Distal (>10kb) Multiome	396
chr19:55,580,080–55,581,090	94.4 kb	Distal (>10kb) Multiome	718
chr19:55,585,644–55,586,314	89.4 kb	Distal (>10kb) Multiome	370
chr19:55,586,698–55,587,594	87.9 kb	Distal (>10kb) Multiome	463
chr19:55,598,551–55,600,991	74.8 kb	Distal (>10kb) Multiome	1018
chr19:55,604,520–55,606,690	69.9 kb	Distal (>10kb) Multiome	820
chr19:55,623,637–55,625,055	50.7 kb	Distal (>10kb) Multiome	650
chr19:55,640,091–55,641,769	34.2 kb	Distal (>10kb) Multiome	821
chr19:55,642,197–55,644,356	31.7 kb	Distal (>10kb) Multiome	884
chr19:55,647,711–55,648,342	27.1 kb	Distal (>10kb) Multiome	671
chr19:55,652,138–55,653,078	22.8 kb	Distal (>10kb) Multiome	105
chr19:55,653,199–55,656,056	20.5 kb	Distal (>10kb) Multiome	1123
chr19:55,671,593–55,671,828	3.4 kb	Proximal (<10kb)	184
chr19:55,674,767–55,675,613	63 bp	At TSS Multiome	765
chr19:55,683,798–55,684,453	8.6 kb	Proximal (<10kb)	318
chr19:57,279,622–57,281,023	1605.1 kb	Distal (>10kb) Multiome HiCAR	1026
chr19:57,434,797–57,436,077	1760.2 kb	Distal (>10kb) Multiome HiCAR	742

Genome Browser

Genomic view of the EPN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.