Contributes to membrane insertase activity. Involved in positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and protein insertion into ER membrane. Located in endoplasmic reticulum membrane and extracellular region. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EMC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EMC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EMC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,203,034–50,204,072 | 273.0 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,205,195–50,205,903 | 271.1 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,311,942–50,312,908 | 164.2 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 162.3 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 160.5 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 150.7 kb | Distal (>10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 147.2 kb | Distal (>10kb) Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 145.6 kb | Distal (>10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 142.9 kb | Distal (>10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 107.6 kb | Distal (>10kb) Multiome HiCAR | 311 | |
| chr19:50,376,225–50,377,452 | 99.9 kb | Distal (>10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 92.3 kb | Distal (>10kb) Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 61.6 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 44.7 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 58 bp | At TSS Multiome | 622 | |
| chr19:50,510,707–50,511,948 | 34.9 kb | Distal (>10kb) Multiome | 794 | |
| chr19:50,556,266–50,557,084 | 80.2 kb | Distal (>10kb) Multiome | 463 | |
| chr19:50,639,246–50,640,210 | 163.2 kb | Distal (>10kb) Multiome | 326 | |
| chr19:50,657,814–50,659,557 | 181.8 kb | Distal (>10kb) Multiome | 790 | |
| chr19:50,723,765–50,725,772 | 248.4 kb | Distal (>10kb) Multiome | 721 | |
| chr19:50,728,202–50,728,738 | 252.0 kb | Distal (>10kb) Multiome | 345 |
Genomic view of the EMC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.