MLST8
MTOR associated protein MLST8 | GBL, GbetaL, Lst8, Pop3

Enables protein serine/threonine kinase activator activity and protein-macromolecule adaptor activity. Involved in TOR signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex; TORC2 complex; and serine/threonine protein kinase complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-7 DE-7.8
Biological processes 34 terms
DNA damage response (GO:0006974)TOR signaling (GO:0031929)TOR signaling (GO:0031929)TORC1 complex (GO:0031931)TORC1 complex (GO:0031931)TORC1 complex (GO:0031931)TORC1 signaling (GO:0038202)TORC1 signaling (GO:0038202)TORC2 complex (GO:0031932)TORC2 complex (GO:0031932)TORC2 complex (GO:0031932)TORC2 signaling (GO:0038203)cellular response to hypoxia (GO:0071456)cellular response to nutrient levels (GO:0031669)cellular response to osmotic stress (GO:0071470)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton organization (GO:0007010)cytosol (GO:0005829)lysosomal membrane (GO:0005765)negative regulation of apoptotic process (GO:0043066)negative regulation of autophagy (GO:0010507)nucleoplasm (GO:0005654)positive regulation of TOR signaling (GO:0032008)positive regulation of cell growth (GO:0030307)positive regulation of glycolytic process (GO:0045821)positive regulation of lipid biosynthetic process (GO:0046889)positive regulation of pentose-phosphate shunt (GO:1905857)protein binding (GO:0005515)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase activity (GO:0004674)protein-macromolecule adaptor activity (GO:0030674)regulation of actin cytoskeleton organization (GO:0032956)regulation of actin cytoskeleton organization (GO:0032956)
Expression (TPM)
MLST8 — as a Regulated Gene

TFs regulating MLST8 0 TFs

Transcription factors with Perturb-seq knockdown data for MLST8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLST8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MLST8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLST8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:1,918,171–1,918,773 287.0 kb Distal (>10kb) Multiome 129
chr16:1,929,283–1,930,271 275.7 kb Distal (>10kb) Multiome 780
chr16:1,942,671–1,943,761 262.1 kb Distal (>10kb) Multiome 750
chr16:1,958,923–1,960,140 246.0 kb Distal (>10kb) Multiome 826
chr16:1,964,300–1,965,434 240.6 kb Distal (>10kb) Multiome 933
chr16:1,971,481–1,972,435 233.5 kb Distal (>10kb) Multiome 1010
chr16:1,979,111–1,980,324 226.1 kb Distal (>10kb) Multiome 296
chr16:1,983,450–1,984,851 221.5 kb Distal (>10kb) Multiome 917
chr16:1,989,307–1,993,568 213.1 kb Distal (>10kb) Multiome 706
chr16:2,003,882–2,004,348 201.4 kb Distal (>10kb) Multiome 619
chr16:2,009,742–2,010,504 195.6 kb Distal (>10kb) Multiome 752
chr16:2,022,700–2,023,923 182.2 kb Distal (>10kb) Multiome 682
chr16:2,026,629–2,027,149 178.6 kb Distal (>10kb) Multiome 249
chr16:2,047,366–2,048,252 157.6 kb Distal (>10kb) Multiome 875
chr16:2,090,476–2,092,232 114.2 kb Distal (>10kb) Multiome 344
chr16:2,135,536–2,136,505 69.3 kb Distal (>10kb) Multiome 263
chr16:2,147,864–2,149,260 57.0 kb Distal (>10kb) Multiome 679
chr16:2,149,550–2,152,180 54.4 kb Distal (>10kb) Multiome 618
chr16:2,152,861–2,153,999 51.8 kb Distal (>10kb) Multiome 734
chr16:2,154,834–2,156,329 49.9 kb Distal (>10kb) Multiome 932
chr16:2,178,140–2,179,722 26.7 kb Distal (>10kb) Multiome 318
chr16:2,196,113–2,196,551 8.9 kb Proximal (<10kb) 167
chr16:2,196,594–2,196,887 8.6 kb Proximal (<10kb) 110
chr16:2,205,129–2,206,297 56 bp At TSS Multiome 887
chr16:2,214,212–2,215,803 9.5 kb Proximal (<10kb) Multiome 953
chr16:2,223,095–2,224,285 18.0 kb Distal (>10kb) Multiome 918
chr16:2,251,044–2,252,460 46.2 kb Distal (>10kb) Multiome 996
chr16:2,267,625–2,269,111 62.8 kb Distal (>10kb) Multiome 1044
chr16:2,339,631–2,342,283 135.4 kb Distal (>10kb) Multiome 1129
chr16:2,428,282–2,429,948 223.8 kb Distal (>10kb) Multiome HiCAR 827
chr16:2,459,524–2,460,612 254.6 kb Distal (>10kb) Multiome HiCAR 670
chr16:2,467,565–2,468,324 262.3 kb Distal (>10kb) Multiome 450
chr16:2,470,913–2,472,223 265.8 kb Distal (>10kb) Multiome 427
chr16:2,473,455–2,476,127 269.7 kb Distal (>10kb) Multiome 719
chr16:2,501,124–2,501,877 296.0 kb Distal (>10kb) Multiome 471
chr16:2,513,006–2,514,809 308.3 kb Distal (>10kb) Multiome HiCAR 818
chr16:2,520,064–2,520,618 314.9 kb Distal (>10kb) Multiome HiCAR 624

Genome Browser

Genomic view of the MLST8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:1,908,171 – 2,530,618
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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