This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for TRIB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:11,829,052–11,830,741 | 886.8 kb | Distal (>10kb) Multiome HiCAR | 941 | |
| chr2:11,863,504–11,864,327 | 853.0 kb | Distal (>10kb) Multiome HiCAR | 541 | |
| chr2:12,434,403–12,435,186 | 282.1 kb | Distal (>10kb) Multiome HiCAR | 219 | |
| chr2:12,714,973–12,715,625 | 1.3 kb | Proximal (<10kb) | 105 | |
| chr2:12,715,841–12,719,440 | 111 bp | At TSS Multiome | 847 | |
| chr2:12,778,345–12,779,614 | 62.2 kb | Distal (>10kb) Multiome | 521 | |
| chr2:12,982,774–12,983,527 | 266.3 kb | Distal (>10kb) Multiome | 78 |
Genomic view of the TRIB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.