This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for SLC11A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC11A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC11A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:50,763,385–50,764,948 | 262.2 kb | Distal (>10kb) Multiome | 1004 | |
| chr12:50,842,736–50,843,181 | 183.4 kb | Distal (>10kb) Multiome | 133 | |
| chr12:51,025,646–51,026,823 | 28 bp | At TSS Multiome | 1016 | |
| chr12:51,028,141–51,028,425 | 1.8 kb | Proximal (<10kb) | 284 | |
| chr12:51,047,625–51,048,573 | 21.8 kb | Distal (>10kb) Multiome | 892 | |
| chr12:51,082,637–51,083,972 | 57.2 kb | Distal (>10kb) Multiome | 937 | |
| chr12:51,172,263–51,173,510 | 146.7 kb | Distal (>10kb) Multiome | 853 | |
| chr12:51,217,044–51,218,599 | 191.7 kb | Distal (>10kb) Multiome | 687 | |
| chr12:51,238,201–51,239,451 | 212.6 kb | Distal (>10kb) Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 243.6 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 294.5 kb | Distal (>10kb) Multiome | 315 |
Genomic view of the SLC11A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.