The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UROS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UROS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UROS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:125,718,882–125,720,201 | 103.7 kb | Distal (>10kb) Multiome | 948 | |
| chr10:125,822,692–125,823,926 | 70 bp | At TSS Multiome | 781 | |
| chr10:125,881,217–125,881,743 | 58.1 kb | Distal (>10kb) Multiome | 141 | |
| chr10:125,895,741–125,896,992 | 73.2 kb | Distal (>10kb) Multiome | 374 |
Genomic view of the UROS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.