This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for MBOAT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MBOAT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MBOAT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:53,889,715–53,890,286 | 299.7 kb | Distal (>10kb) Multiome | 322 | |
| chr19:53,898,176–53,899,412 | 290.7 kb | Distal (>10kb) Multiome | 212 | |
| chr19:53,907,868–53,908,722 | 281.4 kb | Distal (>10kb) Multiome | 276 | |
| chr19:53,941,849–53,943,229 | 247.2 kb | Distal (>10kb) Multiome | 240 | |
| chr19:53,957,309–53,957,858 | 232.1 kb | Distal (>10kb) Multiome | 97 | |
| chr19:53,977,539–53,979,011 | 211.2 kb | Distal (>10kb) Multiome | 412 | |
| chr19:53,979,770–53,982,403 | 208.4 kb | Distal (>10kb) Multiome | 530 | |
| chr19:53,982,560–53,983,015 | 206.8 kb | Distal (>10kb) Multiome | 119 | |
| chr19:54,095,628–54,096,220 | 93.7 kb | Distal (>10kb) Multiome | 457 | |
| chr19:54,102,597–54,103,302 | 86.9 kb | Distal (>10kb) Multiome | 703 | |
| chr19:54,114,870–54,116,009 | 74.2 kb | Distal (>10kb) Multiome | 911 | |
| chr19:54,136,562–54,138,683 | 52.3 kb | Distal (>10kb) Multiome | 751 | |
| chr19:54,159,030–54,160,865 | 29.8 kb | Distal (>10kb) Multiome | 793 | |
| chr19:54,161,897–54,162,738 | 27.2 kb | Distal (>10kb) Multiome | 233 | |
| chr19:54,164,508–54,165,013 | 24.8 kb | Distal (>10kb) Multiome | 183 | |
| chr19:54,172,536–54,173,532 | 16.5 kb | Distal (>10kb) Multiome | 397 | |
| chr19:54,179,952–54,180,330 | 9.3 kb | Proximal (<10kb) | 177 | |
| chr19:54,188,192–54,192,172 | 280 bp | At TSS Multiome | 979 | |
| chr19:54,200,383–54,201,351 | 11.2 kb | Distal (>10kb) Multiome | 891 | |
| chr19:54,208,780–54,209,556 | 19.7 kb | Distal (>10kb) Multiome | 358 | |
| chr19:54,231,547–54,232,136 | 42.2 kb | Distal (>10kb) Multiome | 471 | |
| chr19:54,420,287–54,421,161 | 231.2 kb | Distal (>10kb) Multiome | 334 | |
| chr19:54,430,381–54,431,285 | 241.3 kb | Distal (>10kb) Multiome | 240 | |
| chr19:54,448,346–54,449,853 | 259.6 kb | Distal (>10kb) Multiome | 959 | |
| chr19:54,462,469–54,465,494 | 274.3 kb | Distal (>10kb) Multiome | 1004 |
Genomic view of the MBOAT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.