This module contains 14 genes including ITGA7, SDC3, RAB11FIP2, NEDD1, and PTPRU, with top enriched terms related to cell adhesion molecules, integrin binding, and membrane protein organization. Knockdown of SOX17 activates this module, while knockdown of NANOG and OCT4 repress it. These regulatory relationships suggest that pluripotency factors normally suppress adhesion-related gene expression during the ESC state.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.