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DE-7.9

Submodule 11 genes

Serine protease inhibitors and metabolic enzymes

This module contains 11 genes including SERPING1, LTA4H, BDH2, UROS, and OCIAD1, with enrichment in serine protease inhibitor activity and oxidoreductase function. Knockdown of SOX11 and SETDB1 activates this module. Knockdown of SMARCC1 and ARID1A represses this module.

Key terms: peptide metabolic process organic acid metabolic process carboxylic acid metabolic process heme metabolic process Notable genes: SERPING1 LTA4H BDH2 UROS OCIAD1 YPEL3 GCA TST Top TFs: SOX11 SMARCC1 SETDB1 ARID1A

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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