DE-7 ›

DE-7.7

Submodule 12 genes

Stress response and translational regulation

This 12-gene module includes TDP2, UFM1, SELENOF, EIF2AK1, and MPHOSPH8, with enriched terms related to stress response and translational control. Knockdown of SOX4 and SOX11 activates this module. No repressing transcription factors were identified.

Key terms: negative regulation of intracellular transport negative regulation of intracellular protein transport negative regulation of hemoglobin biosynthetic process negative regulation of translational initiation by iron Notable genes: TDP2 UFM1 SELENOF EIF2AK1 MPHOSPH8 ERLEC1 KDSR TTC19 Top TFs: SOX4 SOX11

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact