chr14:75,228,139–75,228,628

chr14 : 75,228,139 – 75,228,628

489 bp 65 TFs 6 linked genes

This 489 bp open chromatin element is linked to 6 target genes and is bound by 65 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TMED10		51.8 kb	Distal	Multiome+HiCAR
NEK9		101.3 kb	Distal	Multiome
ACYP1		158.9 kb	Distal	Multiome
ZC2HC1C		164.3 kb	Distal	Multiome
MLH3		176.9 kb	Distal	Multiome
EIF2B2		225.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

65 transcription factors

ARID1B 2 datasets

ChIP K-562 ENCSR822CCM.ARID1B.K-562 378 bp overlap

ChIP K562 ENCFF938UXQ 439 bp overlap

ARID2 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.ARID2.BIN-67_lentivirus-SMARCA4-K785R 489 bp overlap

ChIP GM12878 ENCSR014YCR.ATF7.GM12878 328 bp overlap

ChIP K-562 ENCSR808AKZ.BCOR.K-562 215 bp overlap

BHLHE40 2 datasets

ChIP K-562 ENCSR000EGV.BHLHE40.K-562 116 bp overlap

ChIP K562 ENCFF923NJI 205 bp overlap

ChIP MV4-11_DMSO GSE120715.BRD3.MV4-11_DMSO 161 bp overlap

BRD4 7 datasets

ChIP MV4-11-B_BI00894999_100nM_4h GSE101821.BRD4.MV4-11-B_BI00894999_100nM_4h 250 bp overlap

ChIP MV4-11-B_BI00894999_35nM_4h GSE101821.BRD4.MV4-11-B_BI00894999_35nM_4h 231 bp overlap

ChIP MV4-11-B_DMSO GSE101821.BRD4.MV4-11-B_DMSO 346 bp overlap

ChIP MV4-11_DMSO GSE120715.BRD4.MV4-11_DMSO 314 bp overlap

ChIP SW480 GSE73319.BRD4.SW480 433 bp overlap

ChIP THP-1_DMSO GSE138084.BRD4.THP-1_DMSO 297 bp overlap

ChIP THP-1_iBET-BD2 GSE138084.BRD4.THP-1_iBET-BD2 290 bp overlap

CTBP1 1 dataset

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 279 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF896HSY 98 bp overlap

ChIP GM12878 ENCSR509FWH.DPF2.GM12878 487 bp overlap

E2F6 2 datasets

ChIP K-562 ENCSR000EWJ.E2F6.K-562 123 bp overlap

ChIP K-562 ENCSR000BLI.E2F6.K-562 101 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 148 bp overlap

ChIP primary-endometrium-cancer_E1_DSG GSE114737.ESR1.primary-endometrium-cancer_E1_DSG 233 bp overlap

ChIP CTV-1_DSG GSE128835.ETS1.CTV-1_DSG 252 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 385 bp overlap

ChIP DE DE-FOXA2-2 378 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 443 bp overlap

ChIP DE DE-GATA4-2 469 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 451 bp overlap

ChIP DE DE-GATA6-2 487 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 447 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 489 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 339 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 414 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 489 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 435 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 345 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 292 bp overlap

GATAD2B 1 dataset

ChIP GM12878 ENCFF781IAU 299 bp overlap

HDAC1 3 datasets

ChIP K-562 ENCSR711VWL.HDAC1.K-562 244 bp overlap

ChIP K-562 ENCSR387UWP.HDAC1.K-562 383 bp overlap

ChIP K562 ENCFF928TKZ 284 bp overlap

HDAC2 1 dataset

ChIP K-562 ENCSR075HTM.HDAC2.K-562 237 bp overlap

HNF4A 1 dataset

ChIP KATO-III GSE114018.HNF4A.KATO-III 458 bp overlap

IKZF1 5 datasets

ChIP GM12878 ENCFF753XDO 435 bp overlap

ChIP GM12878 ENCFF824TGK 489 bp overlap

ChIP K-562 ENCSR395HWC.IKZF1.K-562 395 bp overlap

ChIP K562 ENCFF348IBL 134 bp overlap

ChIP K562 ENCFF771OHZ 395 bp overlap

IKZF2 6 datasets

ChIP GM12878 ENCFF238LYK 489 bp overlap

ChIP GM12878 ENCFF238LYK 274 bp overlap

ChIP GM12878 ENCFF918AID 489 bp overlap

ChIP GM12878 ENCFF918AID 305 bp overlap

ChIP GM12878 ENCSR680UQE.IKZF2.GM12878 489 bp overlap

ChIP GM12878 ENCSR822AHX.IKZF2.GM12878 454 bp overlap

INTS13 1 dataset

ChIP monocyte GSE106359.INTS13.monocyte 159 bp overlap

ChIP K-562 ENCSR000DJY.JUNB.K-562 388 bp overlap

KDM1A 2 datasets

ChIP Kasumi-1_RN1 GSE71739.KDM1A.Kasumi-1_RN1 249 bp overlap

ChIP SKNO-1_RN1 GSE71739.KDM1A.SKNO-1_RN1 251 bp overlap

KMT2A 1 dataset

ChIP MV4-11 GSE79899.KMT2A.MV4-11 225 bp overlap

L3MBTL2 2 datasets

ChIP K-562 ENCSR530XQI.L3MBTL2.K-562 292 bp overlap

ChIP K562 ENCFF320EQC 340 bp overlap

ChIP TSU-1621MT GSE60477.LMO2.TSU-1621MT 252 bp overlap

MAX 11 datasets

ChIP Hep-G2 ENCSR168DYA.MAX.Hep-G2 132 bp overlap

ChIP K-562 ENCSR000EFV.MAX.K-562 221 bp overlap

ChIP K562 ENCFF110LJS 260 bp overlap

ChIP K562 ENCFF524IJO 243 bp overlap

ChIP NB4 ENCFF966MWB 249 bp overlap

ChIP NB4 ENCSR000EHS.MAX.NB4 129 bp overlap

ChIP P493-6 GSE36354.MAX.P493-6 279 bp overlap

ChIP P493-6 GSE42262.MAX.P493-6 140 bp overlap

ChIP P493-6_CMYC_1H GSE36354.MAX.P493-6_CMYC_1H 243 bp overlap

ChIP P493-6_CMYC_24H GSE36354.MAX.P493-6_CMYC_24H 159 bp overlap

ChIP liver ENCSR847DIT.MAX.liver 140 bp overlap

ChIP K-562 ENCSR710WLO.MGA.K-562 194 bp overlap

ChIP K562 ENCFF140CEX 327 bp overlap

ChIP K-562 ENCSR512NLO.MNT.K-562 298 bp overlap

ChIP K-562 ENCSR390VGH.MNT.K-562 324 bp overlap

ChIP K562 ENCFF820IGH 452 bp overlap

ChIP GM12878 ENCSR293QAR.MTA2.GM12878 199 bp overlap

ChIP K-562 ENCSR000EGJ.MYC.K-562 207 bp overlap

ChIP K562 ENCFF988ZRU 317 bp overlap

ChIP NB4 ENCFF142PRP 269 bp overlap

ChIP P493-6 GSE77061.MYC.P493-6 146 bp overlap

ChIP P493-6_MST-312 GSE77061.MYC.P493-6_MST-312 174 bp overlap

ChIP P493-6_scramble-shRNA GSE101853.MYC.P493-6_scramble-shRNA 290 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 489 bp overlap

NFATC3 1 dataset

ChIP GM12878 ENCSR437GBJ.NFATC3.GM12878 201 bp overlap

NR2F1 1 dataset

ChIP GM12878 ENCSR514VYD.NR2F1.GM12878 254 bp overlap

PKNOX1 1 dataset

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 210 bp overlap

RAD21 3 datasets

ChIP HeLa-S3_CTCF-s-OE GSE108869.RAD21.HeLa-S3_CTCF-s-OE 323 bp overlap

ChIP THP-1_eGFP-IFNb GSE103477.RAD21.THP-1_eGFP-IFNb 148 bp overlap

ChIP peripheral-blood-neutrophil_PMA-1 GSE126755.RAD21.peripheral-blood-neutrophil_PMA-1 253 bp overlap

RELB 2 datasets

ChIP GM12878 ENCFF217ADF 489 bp overlap

ChIP GM12878 ENCSR387QUV.RELB.GM12878 378 bp overlap

ChIP hippocampus GSE144226.REST.hippocampus 177 bp overlap

ChIP GM12878 ENCSR212YKD.SKIL.GM12878 262 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 283 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 367 bp overlap

SMAD2_3 1 dataset

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 314 bp overlap

SMARCA4 3 datasets

ChIP CTV-1_DSG GSE128835.SMARCA4.CTV-1_DSG 268 bp overlap

ChIP CTV-1_FLAG GSE128835.SMARCA4.CTV-1_FLAG 272 bp overlap

ChIP K-562 ENCSR587OQL.SMARCA4.K-562 222 bp overlap

SMARCA5 1 dataset

ChIP GM12878 ENCSR706YUH.SMARCA5.GM12878 192 bp overlap

SMARCC1 2 datasets

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCC1.BIN-67_lentivirus-SMARCA4-K785R 218 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 254 bp overlap

SMARCE1 1 dataset

ChIP K-562 ENCSR157TCS.SMARCE1.K-562 409 bp overlap

SMC1A 1 dataset

ChIP monocyte_INFg GSE98367.SMC1A.monocyte_INFg 264 bp overlap

ChIP peripheral-blood-neutrophil_Ecoli-1 GSE126755.SMC3.peripheral-blood-neutrophil_Ecoli-1 278 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 421 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 486 bp overlap

ChIP K-562 ENCSR788RSW.SOX6.K-562 288 bp overlap

SPI1 28 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 149 bp overlap

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 208 bp overlap

ChIP CTV-1_delA GSE128835.SPI1.CTV-1_delA 215 bp overlap

ChIP CTV-1_delQ GSE128835.SPI1.CTV-1_delQ 251 bp overlap

ChIP CTV-1_delQA GSE128835.SPI1.CTV-1_delQA 227 bp overlap

ChIP DC_LPS GSE123347.SPI1.DC_LPS 126 bp overlap

ChIP EM-3 GSE128834.SPI1.EM-3 204 bp overlap

ChIP GM12891 ENCFF563IUT 206 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 120 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 175 bp overlap

ChIP HL-60 ENCFF645GBT 218 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 185 bp overlap

ChIP K-562 ENCSR000BGW.SPI1.K-562 139 bp overlap

ChIP K-562_NABUT GSE74999.SPI1.K-562_NABUT 148 bp overlap

ChIP Kasumi-1_SICTR GSE60130.SPI1.Kasumi-1_SICTR 199 bp overlap

ChIP Kasumi-1_SIRUNX1ETO GSE60130.SPI1.Kasumi-1_SIRUNX1ETO 221 bp overlap

ChIP NB4 GSE128834.SPI1.NB4 192 bp overlap

ChIP OCI-Ly7 GSE69558.SPI1.OCI-Ly7 183 bp overlap

ChIP THP-1_DIFF GSE25426.SPI1.THP-1_DIFF 134 bp overlap

ChIP U-937 GSE128834.SPI1.U-937 195 bp overlap

ChIP macrophage_D7_donorP GSE128834.SPI1.macrophage_D7_donorP 272 bp overlap

ChIP monocyte GSE31621.SPI1.monocyte 186 bp overlap

ChIP primary-monocyte_18h_donorO GSE128834.SPI1.primary-monocyte_18h_donorO 254 bp overlap

ChIP primary-monocyte_4h_donorO GSE128834.SPI1.primary-monocyte_4h_donorO 200 bp overlap

ChIP primary-monocyte_LPS-4h_donorO GSE128834.SPI1.primary-monocyte_LPS-4h_donorO 167 bp overlap

ChIP primary-monocyte_donorA_ncMO GSE128834.SPI1.primary-monocyte_donorA_ncMO 100 bp overlap

ChIP primary-neutrophil_donorE GSE128834.SPI1.primary-neutrophil_donorE 120 bp overlap

ChIP primary-neutrophil_donorF GSE128834.SPI1.primary-neutrophil_donorF 159 bp overlap

ChIP OCI-Ly3 GSE56857.SPIB.OCI-Ly3 226 bp overlap

SREBP2 2 datasets

ChIP monocyte GSE129202.SREBP2.monocyte 179 bp overlap

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 266 bp overlap

STAT1 1 dataset

ChIP CD14_INFG GSE43036.STAT1.CD14_INFG 131 bp overlap

STAT3 1 dataset

ChIP monocyte_IL10 GSE120943.STAT3.monocyte_IL10 180 bp overlap

TARDBP 1 dataset

ChIP GM12878 ENCSR412QBS.TARDBP.GM12878 276 bp overlap

TBX21 2 datasets

ChIP GM12878 ENCFF951HUW 239 bp overlap

ChIP GM12878 ENCSR739IHN.TBX21.GM12878 489 bp overlap

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 266 bp overlap

TERF1 1 dataset

ChIP LCL GSE55053.TERF1.LCL 135 bp overlap

ChIP THP-1_1d_1-25-OH-2D3 GSE89431.VDR.THP-1_1d_1-25-OH-2D3 109 bp overlap

ZBTB16 1 dataset

ChIP KG-1_shEZH2 GSE109619.ZBTB16.KG-1_shEZH2 168 bp overlap

ZBTB7A 1 dataset

ChIP K-562 GSE103445.ZBTB7A.K-562 137 bp overlap