TMED10
transmembrane p24 trafficking protein 10 | P24(DELTA), TMP21, p23, p24d1, p24delta1

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.16
Biological processes 58 terms
COPI coating of Golgi vesicle (GO:0048205)COPI-coated vesicle (GO:0030137)COPI-coated vesicle (GO:0030137)COPI-coated vesicle budding (GO:0035964)COPII vesicle coating (GO:0048208)COPII-coated ER to Golgi transport vesicle (GO:0030134)ER to Golgi transport vesicle membrane (GO:0012507)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi organization (GO:0007030)Golgi organization (GO:0007030)cis-Golgi network (GO:0005801)cytosol to ERGIC protein transport (GO:0106273)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)gamma-secretase complex (GO:0070765)gamma-secretase complex (GO:0070765)intracellular protein transport (GO:0006886)intracellular protein transport (GO:0006886)melanosome (GO:0042470)membrane (GO:0016020)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of interleukin-1 production (GO:0032732)positive regulation of interleukin-1 production (GO:0032732)positive regulation of protein secretion (GO:0050714)positive regulation of protein secretion (GO:0050714)protein binding (GO:0005515)protein localization to ERGIC (GO:0106272)protein transmembrane transport (GO:0071806)regulated exocytosis (GO:0045055)regulated exocytosis (GO:0045055)regulation of amyloid-beta formation (GO:1902003)retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890)secretory granule membrane (GO:0030667)secretory granule membrane (GO:0030667)syntaxin binding (GO:0019905)trans-Golgi network transport vesicle (GO:0030140)transmembrane protein transporter activity (GO:0008320)transport vesicle (GO:0030133)transport vesicle membrane (GO:0030658)vesicle cargo loading (GO:0035459)vesicle targeting, to, from or within Golgi (GO:0048199)vesicle targeting, to, from or within Golgi (GO:0048199)zymogen granule membrane (GO:0042589)zymogen granule membrane (GO:0042589)
Expression (TPM)
TMED10 — as a Regulated Gene

TFs regulating TMED10 0 TFs

Transcription factors with Perturb-seq knockdown data for TMED10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMED10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TMED10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMED10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:74,879,596–74,880,720 296.6 kb Distal (>10kb) Multiome 108
chr14:74,881,522–74,882,475 294.7 kb Distal (>10kb) Multiome 877
chr14:74,922,804–74,923,467 253.3 kb Distal (>10kb) Multiome 458
chr14:74,955,358–74,956,099 220.9 kb Distal (>10kb) Multiome 457
chr14:74,980,538–74,981,185 195.7 kb Distal (>10kb) Multiome 205
chr14:75,002,395–75,003,398 173.8 kb Distal (>10kb) Multiome 767
chr14:75,050,911–75,051,628 125.3 kb Distal (>10kb) Multiome 749
chr14:75,063,590–75,064,414 112.6 kb Distal (>10kb) Multiome 518
chr14:75,069,008–75,070,183 107.1 kb Distal (>10kb) Multiome 874
chr14:75,126,669–75,127,381 49.6 kb Distal (>10kb) Multiome 888
chr14:75,176,098–75,177,235 215 bp At TSS Multiome 975
chr14:75,196,367–75,197,128 20.1 kb Distal (>10kb) Multiome 438
chr14:75,228,139–75,228,628 51.8 kb Distal (>10kb) Multiome HiCAR 65
chr14:75,229,856–75,230,789 53.8 kb Distal (>10kb) Multiome HiCAR 293
chr14:75,258,653–75,259,760 82.5 kb Distal (>10kb) Multiome 840
chr14:75,276,919–75,277,969 100.5 kb Distal (>10kb) Multiome HiCAR 731
chr14:75,278,060–75,280,702 102.0 kb Distal (>10kb) Multiome HiCAR 928
chr14:75,293,606–75,295,425 117.6 kb Distal (>10kb) Multiome HiCAR 759
chr14:75,295,693–75,296,382 119.6 kb Distal (>10kb) Multiome HiCAR 471
chr14:75,419,070–75,419,695 242.9 kb Distal (>10kb) Multiome 358
chr14:75,427,222–75,428,490 251.3 kb Distal (>10kb) Multiome 640
chr14:75,452,945–75,453,577 276.7 kb Distal (>10kb) Multiome 408

Genome Browser

Genomic view of the TMED10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:74,869,596 – 75,463,577
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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