NEK9
NIMA related kinase 9 | DKFZp434D0935, MGC16714, NERCC, NERCC1, Nek8

This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]

Member of: DE-2 DE-2.4 Developmental clusters: GC2
Biological processes 15 terms
ATP binding (GO:0005524)centrosome (GO:0005813)cytoplasm (GO:0005737)cytosol (GO:0005829)mitotic cell cycle (GO:0000278)mitotic cell cycle (GO:0000278)nucleus (GO:0005634)protein binding (GO:0005515)protein kinase activator activity (GO:0030295)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of mitotic cell cycle (GO:0007346)
Expression (TPM)
NEK9 — as a Regulated Gene

TFs regulating NEK9 0 TFs

Transcription factors with Perturb-seq knockdown data for NEK9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEK9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NEK9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEK9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:74,879,596–74,880,720 247.0 kb Distal (>10kb) Multiome 108
chr14:74,881,522–74,882,475 245.2 kb Distal (>10kb) Multiome 877
chr14:74,922,804–74,923,467 203.8 kb Distal (>10kb) Multiome 458
chr14:74,955,358–74,956,099 171.4 kb Distal (>10kb) Multiome 457
chr14:74,980,538–74,981,185 146.2 kb Distal (>10kb) Multiome 205
chr14:75,002,395–75,003,398 124.3 kb Distal (>10kb) Multiome 767
chr14:75,050,911–75,051,628 75.7 kb Distal (>10kb) Multiome 749
chr14:75,063,590–75,064,414 63.0 kb Distal (>10kb) Multiome 518
chr14:75,069,008–75,070,183 57.5 kb Distal (>10kb) Multiome 874
chr14:75,126,669–75,127,381 48 bp At TSS Multiome 888
chr14:75,176,098–75,177,235 49.8 kb Distal (>10kb) Multiome 975
chr14:75,196,367–75,197,128 69.7 kb Distal (>10kb) Multiome 438
chr14:75,228,139–75,228,628 101.3 kb Distal (>10kb) Multiome 65
chr14:75,229,856–75,230,789 103.4 kb Distal (>10kb) Multiome 293
chr14:75,258,653–75,259,760 132.1 kb Distal (>10kb) Multiome 840
chr14:75,276,919–75,277,969 150.1 kb Distal (>10kb) Multiome HiCAR 731
chr14:75,278,060–75,280,702 151.6 kb Distal (>10kb) Multiome HiCAR 928
chr14:75,293,606–75,295,425 167.2 kb Distal (>10kb) Multiome HiCAR 759
chr14:75,295,693–75,296,382 169.2 kb Distal (>10kb) Multiome HiCAR 471
chr14:75,419,070–75,419,695 292.4 kb Distal (>10kb) Multiome 358

Genome Browser

Genomic view of the NEK9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:74,869,596 – 75,429,695
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact