EIF2B2

eukaryotic translation initiation factor 2B subunit beta | EIF-2Bbeta, EIF2B, EIF2Bbeta

This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]

Member of: DE-1

Biological processes 30 terms

ATP binding (GO:0005524)GTP binding (GO:0005525)T cell receptor signaling pathway (GO:0050852)animal organ development (GO:0048513)central nervous system development (GO:0007417)central nervous system development (GO:0007417)cytoplasm (GO:0005737)cytoplasmic translational initiation (GO:0002183)cytosol (GO:0005829)cytosol (GO:0005829)eukaryotic translation initiation factor 2B complex (GO:0005851)eukaryotic translation initiation factor 2B complex (GO:0005851)eukaryotic translation initiation factor 2B complex (GO:0005851)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)myelination (GO:0042552)oligodendrocyte development (GO:0014003)ovarian follicle development (GO:0001541)positive regulation of translational initiation (GO:0045948)protein binding (GO:0005515)regulation of translational initiation (GO:0006446)response to glucose (GO:0009749)response to heat (GO:0009408)response to heat (GO:0009408)response to peptide hormone (GO:0043434)translation initiation factor activity (GO:0003743)translational initiation (GO:0006413)translational initiation (GO:0006413)

Expression (TPM)

TFs regulating EIF2B2 0 TFs

Transcription factors with Perturb-seq knockdown data for EIF2B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF2B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to EIF2B2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF2B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:74,763,078–74,763,795	239.6 kb	Distal (>10kb) Multiome	808
chr14:74,879,596–74,880,720	122.9 kb	Distal (>10kb) Multiome	108
chr14:74,881,522–74,882,475	121.0 kb	Distal (>10kb) Multiome	877
chr14:74,922,804–74,923,467	79.7 kb	Distal (>10kb) Multiome	458
chr14:74,955,358–74,956,099	47.2 kb	Distal (>10kb) Multiome HiCAR	457
chr14:74,980,538–74,981,185	22.0 kb	Distal (>10kb) Multiome	205
chr14:75,002,395–75,003,398	130 bp	At TSS Multiome	767
chr14:75,050,911–75,051,628	48.4 kb	Distal (>10kb) Multiome	749
chr14:75,063,590–75,064,414	61.1 kb	Distal (>10kb) Multiome	518
chr14:75,069,008–75,070,183	66.6 kb	Distal (>10kb) Multiome	874
chr14:75,126,669–75,127,381	124.1 kb	Distal (>10kb) Multiome	888
chr14:75,176,098–75,177,235	173.9 kb	Distal (>10kb) Multiome	975
chr14:75,196,367–75,197,128	193.8 kb	Distal (>10kb) Multiome	438
chr14:75,228,139–75,228,628	225.4 kb	Distal (>10kb) Multiome	65
chr14:75,229,856–75,230,789	227.5 kb	Distal (>10kb) Multiome	293
chr14:75,258,653–75,259,760	256.2 kb	Distal (>10kb) Multiome	840
chr14:75,276,919–75,277,969	274.2 kb	Distal (>10kb) Multiome	731
chr14:75,278,060–75,280,702	275.7 kb	Distal (>10kb) Multiome	928
chr14:75,293,606–75,295,425	291.3 kb	Distal (>10kb) Multiome	759
chr14:75,295,693–75,296,382	293.3 kb	Distal (>10kb) Multiome	471

Genome Browser

Genomic view of the EIF2B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.