chr6 : 46,485,645 – 46,486,451
806 bp 84 TFs 3 linked genes
This 806 bp open chromatin element is linked to RCAN2, RCAN2-DT, and SLC25A27 and is bound by 84 transcription factors.
Linked Genes
3 genes
Distance
Link type
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
RCAN2 5.0 kb Proximal Proximity
RCAN2-DT 5.6 kb Proximal Proximity
SLC25A27 166.7 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr6:46,480,645 – 46,491,451
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
84 transcription factors
Source
Cell type
Arid3a 3 datasets
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap
CHD7 1 dataset
ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 174 bp overlap
CTCF 2 datasets
Motif DE_48h DE_48h-CTCF_MA1929.2 31 bp overlap
Motif DE_60h DE_60h-CTCF_MA1929.2 31 bp overlap
Crx 3 datasets
Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap
Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap
Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap
DMRTA1 3 datasets
Motif DE_48h DE_48h-DMRTA1_MA1707.2 10 bp overlap
Motif DE_60h DE_60h-DMRTA1_MA1707.2 10 bp overlap
Motif DE_72h DE_72h-DMRTA1_MA1707.2 10 bp overlap
Dmbx1 3 datasets
Motif DE_48h DE_48h-Dmbx1_MA0883.2 10 bp overlap
Motif DE_60h DE_60h-Dmbx1_MA0883.2 10 bp overlap
Motif DE_72h DE_72h-Dmbx1_MA0883.2 10 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 452 bp overlap
ERG 1 dataset
ChIP aortic-endothelial-cell_D16 GSE139377.ERG.aortic-endothelial-cell_D16 154 bp overlap
ESRRA 1 dataset
Motif DE_48h DE_48h-ESRRA_MA0592.4 9 bp overlap
ESRRB 1 dataset
Motif DE_48h DE_48h-ESRRB_MA0141.4 10 bp overlap
ESRRG 1 dataset
ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 806 bp overlap
ETV5::FOXI1 1 dataset
Motif DE_48h DE_48h-ETV5FOXI1_MA1946.2 12 bp overlap
Esrrg 1 dataset
Motif DE_48h DE_48h-Esrrg_MA0643.2 9 bp overlap
FOXA2 5 datasets
ChIP DE DE-FOXA2-1 721 bp overlap
ChIP DE DE-FOXA2-2 755 bp overlap
Motif DE_36h DE_36h-FOXA2_MA0047.4 8 bp overlap
Motif DE_48h DE_48h-FOXA2_MA0047.4 8 bp overlap
Motif DE_60h DE_60h-FOXA2_MA0047.4 8 bp overlap
FOXA3 3 datasets
Motif DE_36h DE_36h-FOXA3_MA1683.2 7 bp overlap
Motif DE_48h DE_48h-FOXA3_MA1683.2 7 bp overlap
Motif DE_60h DE_60h-FOXA3_MA1683.2 7 bp overlap
FOXB1 3 datasets
Motif DE_36h DE_36h-FOXB1_MA0845.1 11 bp overlap
Motif DE_48h DE_48h-FOXB1_MA0845.1 11 bp overlap
Motif DE_60h DE_60h-FOXB1_MA0845.1 11 bp overlap
FOXI1 3 datasets
Motif DE_36h DE_36h-FOXI1_MA0042.2 7 bp overlap
Motif DE_48h DE_48h-FOXI1_MA0042.2 7 bp overlap
Motif DE_60h DE_60h-FOXI1_MA0042.2 7 bp overlap
FOXO1::ELF1 1 dataset
Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap
FOXO1::ELK3 1 dataset
Motif DE_48h DE_48h-FOXO1ELK3_MA1955.2 13 bp overlap
FOXP1 3 datasets
Motif DE_36h DE_36h-FOXP1_MA0481.4 7 bp overlap
Motif DE_48h DE_48h-FOXP1_MA0481.4 7 bp overlap
Motif DE_60h DE_60h-FOXP1_MA0481.4 7 bp overlap
FOXP4 3 datasets
Motif DE_36h DE_36h-FOXP4_MA2117.1 7 bp overlap
Motif DE_48h DE_48h-FOXP4_MA2117.1 7 bp overlap
Motif DE_60h DE_60h-FOXP4_MA2117.1 7 bp overlap
FOXS1 3 datasets
Motif DE_36h DE_36h-FOXS1_MA2118.1 8 bp overlap
Motif DE_48h DE_48h-FOXS1_MA2118.1 8 bp overlap
Motif DE_60h DE_60h-FOXS1_MA2118.1 8 bp overlap
Foxl2 3 datasets
Motif DE_36h DE_36h-Foxl2_MA1607.2 10 bp overlap
Motif DE_48h DE_48h-Foxl2_MA1607.2 10 bp overlap
Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap
GATA4 11 datasets
ChIP DE DE-GATA4-1 720 bp overlap
ChIP DE DE-GATA4-2 707 bp overlap
ChIP G296S GSE85628.GATA4.G296S 190 bp overlap
ChIP G296S_2 GSE85628.GATA4.G296S_2 190 bp overlap
ChIP Hep-G2 GSE135714.GATA4.Hep-G2 314 bp overlap
ChIP cardiomyocyte GSE85628.GATA4.cardiomyocyte 346 bp overlap
ChIP cardiomyocyte_1 GSE85628.GATA4.cardiomyocyte_1 354 bp overlap
ChIP cardiomyocyte_5 GSE85628.GATA4.cardiomyocyte_5 551 bp overlap
ChIP cardiomyocyte_7 GSE85628.GATA4.cardiomyocyte_7 381 bp overlap
ChIP foregut GSE117136.GATA4.foregut 452 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 416 bp overlap
GATA5 3 datasets
Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap
Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap
Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap
GATA6 11 datasets
ChIP DE DE-GATA6-1 651 bp overlap
ChIP DE DE-GATA6-2 796 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 380 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 576 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 281 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 692 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 543 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 401 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 539 bp overlap
ChIP foregut GSE117136.GATA6.foregut 402 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 334 bp overlap
GSC 3 datasets
Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap
Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap
Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap
GSC2 3 datasets
Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap
Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap
Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap
HAND2 3 datasets
Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap
Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap
Motif DE_72h DE_72h-HAND2_MA1638.2 6 bp overlap
HIF1A 1 dataset
ChIP U2OS_DMSO GSE85096.HIF1A.U2OS_DMSO 201 bp overlap
HSF2 3 datasets
Motif DE_48h DE_48h-HSF2_MA0770.1 13 bp overlap
Motif DE_60h DE_60h-HSF2_MA0770.1 13 bp overlap
Motif DE_72h DE_72h-HSF2_MA0770.1 13 bp overlap
JUN 1 dataset
ChIP DE_D2 S02-DE-d2-JUN-exp1 436 bp overlap
JUND 3 datasets
Motif DE_48h DE_48h-JUND_MA0492.2 11 bp overlap
Motif DE_60h DE_60h-JUND_MA0492.2 11 bp overlap
Motif DE_72h DE_72h-JUND_MA0492.2 11 bp overlap
MED1 9 datasets
ChIP G296S GSE85628.MED1.G296S 455 bp overlap
ChIP G296S_2 GSE85628.MED1.G296S_2 455 bp overlap
ChIP G296S_4 GSE85628.MED1.G296S_4 665 bp overlap
ChIP G296S_4 GSE85628.MED1.G296S_4 76 bp overlap
ChIP cardiomyocyte GSE85628.MED1.cardiomyocyte 315 bp overlap
ChIP cardiomyocyte_1 GSE85628.MED1.cardiomyocyte_1 316 bp overlap
ChIP cardiomyocyte_5 GSE85628.MED1.cardiomyocyte_5 116 bp overlap
ChIP cardiomyocyte_5 GSE85628.MED1.cardiomyocyte_5 469 bp overlap
ChIP cardiomyocyte_7 GSE85628.MED1.cardiomyocyte_7 224 bp overlap
MEF2A 3 datasets
Motif DE_36h DE_36h-MEF2A_MA0052.5 10 bp overlap
Motif DE_48h DE_48h-MEF2A_MA0052.5 10 bp overlap
Motif DE_60h DE_60h-MEF2A_MA0052.5 10 bp overlap
MEF2B 3 datasets
Motif DE_36h DE_36h-MEF2B_MA0660.1 12 bp overlap
Motif DE_48h DE_48h-MEF2B_MA0660.1 12 bp overlap
Motif DE_60h DE_60h-MEF2B_MA0660.1 12 bp overlap
MEF2D 3 datasets
Motif DE_36h DE_36h-MEF2D_MA0773.1 12 bp overlap
Motif DE_48h DE_48h-MEF2D_MA0773.1 12 bp overlap
Motif DE_60h DE_60h-MEF2D_MA0773.1 12 bp overlap
Msgn1 1 dataset
Motif DE_48h DE_48h-Msgn1_MA1524.3 10 bp overlap
NEUROD1 3 datasets
ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 231 bp overlap
ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 306 bp overlap
ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 211 bp overlap
NEUROG2 1 dataset
Motif DE_48h DE_48h-NEUROG2_MA0669.1 10 bp overlap
NKX2-2 3 datasets
Motif DE_36h DE_36h-NKX2-2_MA1645.2 8 bp overlap
Motif DE_48h DE_48h-NKX2-2_MA1645.2 8 bp overlap
Motif DE_60h DE_60h-NKX2-2_MA1645.2 8 bp overlap
NR1D2 1 dataset
Motif DE_48h DE_48h-NR1D2_MA1532.2 15 bp overlap
NR2C1 2 datasets
Motif DE_48h DE_48h-NR2C1_MA1535.2 6 bp overlap
Motif DE_48h DE_48h-NR2C1_MA1535.2 6 bp overlap
NR2C2 2 datasets
Motif DE_48h DE_48h-NR2C2_MA1536.2 6 bp overlap
Motif DE_48h DE_48h-NR2C2_MA1536.2 6 bp overlap
NR2F2 1 dataset
Motif DE_48h DE_48h-NR2F2_MA1111.2 7 bp overlap
NR5A1 1 dataset
Motif DE_48h DE_48h-NR5A1_MA1540.3 12 bp overlap
NR6A1 1 dataset
Motif DE_48h DE_48h-NR6A1_MA1541.2 14 bp overlap
Nr1H2 2 datasets
Motif DE_48h DE_48h-Nr1H2_MA1996.2 6 bp overlap
Motif DE_48h DE_48h-Nr1H2_MA1996.2 6 bp overlap
Nr1H4 2 datasets
Motif DE_48h DE_48h-Nr1H4_MA1110.3 6 bp overlap
Motif DE_48h DE_48h-Nr1H4_MA1110.3 6 bp overlap
Nr1h3 2 datasets
Motif DE_48h DE_48h-Nr1h3_MA2337.1 6 bp overlap
Motif DE_48h DE_48h-Nr1h3_MA2337.1 6 bp overlap
Nr5A2 1 dataset
Motif DE_48h DE_48h-Nr5A2_MA0505.3 9 bp overlap
OTX1 3 datasets
Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap
Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap
Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap
PITX1 3 datasets
Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap
Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap
Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap
PITX2 3 datasets
Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap
Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap
Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap
PITX3 3 datasets
Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap
Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap
Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap
PKNOX1 4 datasets
ChIP HEK293T ENCFF174WDB 196 bp overlap
ChIP HEK293T ENCSR233FAG.PKNOX1.HEK293T 150 bp overlap
ChIP K-562 ENCSR115SMW.PKNOX1.K-562 154 bp overlap
ChIP MCF-7 ENCSR986XYK.PKNOX1.MCF-7 136 bp overlap
Ppara 1 dataset
Motif DE_48h DE_48h-Ppara_MA2338.1 7 bp overlap
Ptf1A 3 datasets
Motif DE_48h DE_48h-Ptf1A_MA1618.2 9 bp overlap
Motif DE_60h DE_60h-Ptf1A_MA1618.2 9 bp overlap
Motif DE_72h DE_72h-Ptf1A_MA1618.2 9 bp overlap
RBPJ 1 dataset
Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap
RELB 3 datasets
Motif DE_36h DE_36h-RELB_MA1117.2 7 bp overlap
Motif DE_48h DE_48h-RELB_MA1117.2 7 bp overlap
Motif DE_60h DE_60h-RELB_MA1117.2 7 bp overlap
RHOXF1 3 datasets
Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap
RORA 1 dataset
Motif DE_48h DE_48h-RORA_MA0071.1 10 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 190 bp overlap
SMAD2-3 1 dataset
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 517 bp overlap
SMAD2_3 2 datasets
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 548 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 439 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 208 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 368 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 664 bp overlap
SOX2 1 dataset
ChIP hiPSC_KDP53 GSE67282.SOX2.hiPSC_KDP53 251 bp overlap
T 1 dataset
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 351 bp overlap
TBX5 3 datasets
ChIP cardiomyocyte_5 GSE85628.TBX5.cardiomyocyte_5 302 bp overlap
ChIP cardiomyocyte_7 GSE85628.TBX5.cardiomyocyte_7 141 bp overlap
ChIP cardiomyocyte_7 GSE85628.TBX5.cardiomyocyte_7 467 bp overlap
TFAP2A 2 datasets
Motif DE_48h DE_48h-TFAP2A_MA0003.5 9 bp overlap
Motif DE_60h DE_60h-TFAP2A_MA0003.5 9 bp overlap
TFAP2C 2 datasets
Motif DE_48h DE_48h-TFAP2C_MA0814.3 9 bp overlap
Motif DE_60h DE_60h-TFAP2C_MA0814.3 9 bp overlap
TWIST1 3 datasets
Motif DE_48h DE_48h-TWIST1_MA1123.3 8 bp overlap
Motif DE_60h DE_60h-TWIST1_MA1123.3 8 bp overlap
Motif DE_72h DE_72h-TWIST1_MA1123.3 8 bp overlap
ZBTB12 2 datasets
Motif DE_48h DE_48h-ZBTB12_MA1649.2 7 bp overlap
Motif DE_72h DE_72h-ZBTB12_MA1649.2 7 bp overlap
ZBTB18 3 datasets
Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_72h DE_72h-ZBTB18_MA0698.2 11 bp overlap
ZBTB6 1 dataset
Motif DE_48h DE_48h-ZBTB6_MA1581.2 9 bp overlap
ZNF189 1 dataset
Motif DE_48h DE_48h-ZNF189_MA1725.2 9 bp overlap
ZNF320 3 datasets
Motif DE_36h DE_36h-ZNF320_MA1976.2 20 bp overlap
Motif DE_48h DE_48h-ZNF320_MA1976.2 20 bp overlap
Motif DE_60h DE_60h-ZNF320_MA1976.2 20 bp overlap
ZNF331 3 datasets
Motif DE_48h DE_48h-ZNF331_MA1726.2 10 bp overlap
Motif DE_60h DE_60h-ZNF331_MA1726.2 10 bp overlap
Motif DE_72h DE_72h-ZNF331_MA1726.2 10 bp overlap
ZNF343 1 dataset
Motif DE_48h DE_48h-ZNF343_MA1711.2 16 bp overlap
ZNF549 1 dataset
Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap
ZNF701 3 datasets
Motif DE_36h DE_36h-ZNF701_MA1987.2 17 bp overlap
Motif DE_48h DE_48h-ZNF701_MA1987.2 17 bp overlap
Motif DE_60h DE_60h-ZNF701_MA1987.2 17 bp overlap
ZSCAN4 3 datasets
Motif DE_36h DE_36h-ZSCAN4_MA1155.1 15 bp overlap
Motif DE_48h DE_48h-ZSCAN4_MA1155.1 15 bp overlap
Motif DE_60h DE_60h-ZSCAN4_MA1155.1 15 bp overlap
Huangfu Lab · Publications · Resources · Contact