This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for NR1D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NR1D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NR1D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:23,701,633–23,702,476 | 243.4 kb | Distal (>10kb) Multiome | 210 | |
| chr3:23,805,437–23,807,461 | 139.4 kb | Distal (>10kb) Multiome | 636 | |
| chr3:23,809,943–23,811,474 | 134.7 kb | Distal (>10kb) Multiome | 685 | |
| chr3:23,916,365–23,917,803 | 28.3 kb | Distal (>10kb) Multiome | 1082 | |
| chr3:23,938,713–23,939,267 | 6.3 kb | Proximal (<10kb) Multiome | 172 | |
| chr3:23,943,707–23,944,084 | 1.2 kb | Proximal (<10kb) | 32 | |
| chr3:23,944,552–23,946,922 | 215 bp | At TSS Multiome | 1112 | |
| chr3:23,953,236–23,954,388 | 8.5 kb | Proximal (<10kb) Multiome | 152 | |
| chr3:23,954,521–23,954,663 | 9.2 kb | Proximal (<10kb) | 9 |
Genomic view of the NR1D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.