ZNF343

zinc finger protein 343 | MGC10715

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 10 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating ZNF343 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF343. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF343 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF343

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF343, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:2,351,893–2,352,388	157.1 kb	Distal (>10kb) Multiome	361
chr20:2,470,152–2,471,296	38.3 kb	Distal (>10kb) Multiome	1126
chr20:2,508,648–2,509,663	64 bp	At TSS Multiome	854
chr20:2,509,937–2,510,112	805 bp	At TSS	92
chr20:2,510,228–2,510,373	1.1 kb	Proximal (<10kb)	28
chr20:2,524,432–2,525,455	15.5 kb	Distal (>10kb) Multiome	724
chr20:2,536,033–2,536,583	27.2 kb	Distal (>10kb) Multiome	42
chr20:2,651,802–2,653,286	143.4 kb	Distal (>10kb) Multiome	1060
chr20:2,663,925–2,664,409	155.1 kb	Distal (>10kb) Multiome	908
chr20:2,692,159–2,694,013	183.5 kb	Distal (>10kb) Multiome	584
chr20:2,752,636–2,753,047	243.6 kb	Distal (>10kb) Multiome	395
chr20:2,800,326–2,801,021	291.6 kb	Distal (>10kb) Multiome	349

Genome Browser

Genomic view of the ZNF343 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.