The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for HSF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:122,392,658–122,393,793 | 5.9 kb | Proximal (<10kb) | 176 | |
| chr6:122,399,121–122,400,368 | 81 bp | At TSS Multiome | 922 | |
| chr6:122,405,533–122,405,702 | 5.9 kb | Proximal (<10kb) | 13 | |
| chr6:122,471,228–122,472,247 | 72.2 kb | Distal (>10kb) Multiome | 823 | |
| chr6:122,609,513–122,611,433 | 210.8 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the HSF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.