This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for RCAN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCAN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCAN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:46,468,423–46,469,444 | 22.6 kb | Distal (>10kb) Multiome | 97 | |
| chr6:46,483,245–46,483,500 | 7.9 kb | Proximal (<10kb) | 13 | |
| chr6:46,484,363–46,485,010 | 6.4 kb | Proximal (<10kb) | 81 | |
| chr6:46,485,645–46,486,451 | 5.2 kb | Proximal (<10kb) Multiome | 84 | |
| chr6:46,490,464–46,492,348 | 63 bp | At TSS Multiome | 545 | |
| chr6:46,526,311–46,527,373 | 35.4 kb | Distal (>10kb) Multiome | 184 | |
| chr6:46,652,280–46,653,567 | 161.5 kb | Distal (>10kb) Multiome | 662 | |
| chr6:46,733,963–46,735,949 | 243.9 kb | Distal (>10kb) Multiome | 489 | |
| chr6:46,749,672–46,750,206 | 258.4 kb | Distal (>10kb) Multiome | 168 | |
| chr6:46,790,261–46,790,955 | 299.2 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the RCAN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.