chr12:54,452,678–54,453,187

chr12 : 54,452,678 – 54,453,187

509 bp 54 TFs 6 linked genes

This 509 bp open chromatin element is linked to 6 target genes and is bound by 54 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ITGA5		33.6 kb	Distal	Multiome
COPZ1		127.7 kb	Distal	Multiome
HNRNPA1		172.1 kb	Distal	Multiome
CBX5		172.7 kb	Distal	Multiome
ENSG00000289154		173.1 kb	Distal	Multiome
SMUG1		263.9 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

54 transcription factors

ChIP 22Rv1_R1881 GSE80742.AR.22Rv1_R1881 68 bp overlap

ChIP LNCaP GSE80256.AR.LNCaP 276 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 190 bp overlap

BCL11A 2 datasets

ChIP H1 ENCFF833IPY 145 bp overlap

ChIP WA01 ENCSR000BIP.BCL11A.WA01 143 bp overlap

BCOR 4 datasets

ChIP WA01 GSE104690.BCOR.WA01 264 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 365 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 229 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 229 bp overlap

CEBPB 1 dataset

ChIP WA01 ENCSR000EBV.CEBPB.WA01 233 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 357 bp overlap

CREB1 1 dataset

ChIP WA01 ENCSR000BSN.CREB1.WA01 149 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 275 bp overlap

ChIP VCaP_ETOH GSE49091.ERG.VCaP_ETOH 147 bp overlap

ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 235 bp overlap

ChIP DND41 ENCSR000ASW.EZH2.DND41 369 bp overlap

FEZF1 4 datasets

ChIP HEK293 ENCFF528YED 349 bp overlap

ChIP HEK293 ENCFF528YED 400 bp overlap

ChIP HEK293 ENCSR827NWO.FEZF1.HEK293 350 bp overlap

ChIP HEK293 GSE76494.FEZF1.HEK293 141 bp overlap

FOXA2 3 datasets

ChIP Caco-2 GSE66218.FOXA2.Caco-2 99 bp overlap

ChIP DE DE-FOXA2-1 499 bp overlap

ChIP DE DE-FOXA2-2 496 bp overlap

FOXP1 1 dataset

ChIP H9 GSE31006.FOXP1.H9 253 bp overlap

GABPA 1 dataset

ChIP VCaP_R1881 GSE49091.GABPA.VCaP_R1881 142 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 419 bp overlap

ChIP DE DE-GATA4-2 509 bp overlap

ChIP foregut GSE117136.GATA4.foregut 500 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 481 bp overlap

ChIP DE DE-GATA6-2 509 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 418 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 502 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 391 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 422 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 420 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 418 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 422 bp overlap

ChIP foregut GSE117136.GATA6.foregut 509 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 509 bp overlap

GLIS1 1 dataset

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 196 bp overlap

HDAC2 1 dataset

ChIP WA01 ENCSR000BNR.HDAC2.WA01 164 bp overlap

IRF2BP2 1 dataset

ChIP HEK293 GSE124636.IRF2BP2.HEK293 211 bp overlap

JARID2 1 dataset

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 362 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 274 bp overlap

ChIP WA01 ENCSR000EUP.MAX.WA01 138 bp overlap

NANOG 11 datasets

ChIP GM23338 ENCFF065NZG 289 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 212 bp overlap

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 458 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 440 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 254 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 509 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 441 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 408 bp overlap

ChIP hESC GSE20650.NANOG.hESC 311 bp overlap

ChIP hESC GSE18292.NANOG.hESC 143 bp overlap

ChIP Ishikawa ENCSR000BUT.NFIC.Ishikawa 173 bp overlap

NIPBL 3 datasets

ChIP WA09_heat-shock GSE105028.NIPBL.WA09_heat-shock 294 bp overlap

ChIP hESC_WNT3A GSE64758.NIPBL.hESC_WNT3A 301 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 311 bp overlap

NR3C1 1 dataset

ChIP U2OS_SHHIC5 GSE65847.NR3C1.U2OS_SHHIC5 189 bp overlap

ChIP HEK293 ENCSR324LTM.OSR2.HEK293 222 bp overlap

ChIP WTC11 ENCFF634NAO 245 bp overlap

ChIP T-47D_R5020-MTVL GSE126859.PGR.T-47D_R5020-MTVL 79 bp overlap

POU5F1 7 datasets

ChIP BG03 GSE21614.POU5F1.BG03 153 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 476 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 381 bp overlap

ChIP WA09_heat-shock GSE105028.POU5F1.WA09_heat-shock 223 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 400 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 396 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 296 bp overlap

RBFOX2 2 datasets

ChIP K-562 ENCSR822LBD.RBFOX2.K-562 158 bp overlap

ChIP K-562 GSE120104.RBFOX2.K-562 194 bp overlap

RNF2 3 datasets

ChIP WA01 GSE104690.RNF2.WA01 276 bp overlap

ChIP WA09 GSE105028.RNF2.WA09 299 bp overlap

ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 304 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 421 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 328 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 277 bp overlap

SMAD2_3 1 dataset

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 312 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 169 bp overlap

SMAD5 1 dataset

ChIP K-562 ENCSR000FCD.SMAD5.K-562 99 bp overlap

SMARCA4 2 datasets

ChIP hiPSC GSE124903.SMARCA4.hiPSC 445 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 296 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 482 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 79 bp overlap

SMARCC1 4 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 327 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 464 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 352 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 283 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 205 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 266 bp overlap

SOX2 2 datasets

ChIP hESC GSE18292.SOX2.hESC 133 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 347 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 382 bp overlap

SUPT5H 1 dataset

ChIP HCT-116_pThr806 GSE138548.SUPT5H.HCT-116_pThr806 358 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 287 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 140 bp overlap

ChIP NPC GSE154479.TCF3.NPC 261 bp overlap

TEAD1 1 dataset

ChIP WTC11 ENCFF502QUV 331 bp overlap

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 295 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 167 bp overlap

ChIP HEK293 ENCFF033NQQ 264 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 272 bp overlap

ChIP K-562 ENCSR780BBJ.ZZZ3.K-562 253 bp overlap