Transcription factors with Perturb-seq knockdown data for ENSG00000289154. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289154 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289154, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:53,984,667–53,985,381 | 294.6 kb | Distal (>10kb) Multiome | 456 | |
| chr12:54,017,619–54,018,921 | 261.7 kb | Distal (>10kb) Multiome | 663 | |
| chr12:54,125,925–54,126,686 | 153.5 kb | Distal (>10kb) Multiome | 244 | |
| chr12:54,159,055–54,159,510 | 120.4 kb | Distal (>10kb) Multiome | 263 | |
| chr12:54,188,672–54,189,215 | 90.7 kb | Distal (>10kb) Multiome | 529 | |
| chr12:54,214,692–54,215,229 | 64.8 kb | Distal (>10kb) Multiome | 646 | |
| chr12:54,216,935–54,217,348 | 62.6 kb | Distal (>10kb) Multiome | 450 | |
| chr12:54,217,640–54,218,303 | 61.6 kb | Distal (>10kb) Multiome | 212 | |
| chr12:54,259,188–54,260,497 | 20.0 kb | Distal (>10kb) Multiome HiCAR | 573 | |
| chr12:54,279,361–54,281,440 | 910 bp | At TSS Multiome | 1100 | |
| chr12:54,288,499–54,288,982 | 8.8 kb | Proximal (<10kb) | 311 | |
| chr12:54,300,732–54,301,299 | 21.4 kb | Distal (>10kb) Multiome | 545 | |
| chr12:54,324,486–54,325,464 | 45.3 kb | Distal (>10kb) Multiome | 885 | |
| chr12:54,358,730–54,359,779 | 79.6 kb | Distal (>10kb) Multiome | 857 | |
| chr12:54,370,156–54,370,782 | 90.8 kb | Distal (>10kb) Multiome | 399 | |
| chr12:54,378,747–54,380,140 | 99.5 kb | Distal (>10kb) Multiome | 649 | |
| chr12:54,390,265–54,391,699 | 111.7 kb | Distal (>10kb) Multiome | 393 | |
| chr12:54,419,123–54,419,837 | 139.7 kb | Distal (>10kb) Multiome | 441 | |
| chr12:54,431,650–54,432,865 | 152.4 kb | Distal (>10kb) Multiome | 498 | |
| chr12:54,452,678–54,453,187 | 173.1 kb | Distal (>10kb) Multiome | 54 | |
| chr12:54,549,254–54,550,339 | 269.9 kb | Distal (>10kb) Multiome | 365 | |
| chr12:54,579,588–54,580,234 | 300.2 kb | Distal (>10kb) Multiome | 271 |
Genomic view of the ENSG00000289154 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.