This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for COPZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:54,125,925–54,126,686 | 199.0 kb | Distal (>10kb) Multiome | 244 | |
| chr12:54,159,055–54,159,510 | 165.8 kb | Distal (>10kb) Multiome | 263 | |
| chr12:54,188,672–54,189,215 | 136.1 kb | Distal (>10kb) Multiome | 529 | |
| chr12:54,214,692–54,215,229 | 110.2 kb | Distal (>10kb) Multiome | 646 | |
| chr12:54,216,935–54,217,348 | 108.0 kb | Distal (>10kb) Multiome HiCAR | 450 | |
| chr12:54,217,640–54,218,303 | 107.0 kb | Distal (>10kb) Multiome HiCAR | 212 | |
| chr12:54,259,188–54,260,497 | 65.4 kb | Distal (>10kb) Multiome HiCAR | 573 | |
| chr12:54,279,361–54,281,440 | 44.5 kb | Distal (>10kb) Multiome HiCAR | 1100 | |
| chr12:54,300,732–54,301,299 | 24.1 kb | Distal (>10kb) Multiome HiCAR | 545 | |
| chr12:54,324,486–54,325,464 | 162 bp | At TSS Multiome | 885 | |
| chr12:54,358,730–54,359,779 | 34.2 kb | Distal (>10kb) Multiome HiCAR | 857 | |
| chr12:54,370,156–54,370,782 | 45.3 kb | Distal (>10kb) Multiome | 399 | |
| chr12:54,378,747–54,380,140 | 54.1 kb | Distal (>10kb) Multiome | 649 | |
| chr12:54,390,265–54,391,699 | 66.2 kb | Distal (>10kb) Multiome | 393 | |
| chr12:54,419,123–54,419,837 | 94.3 kb | Distal (>10kb) Multiome | 441 | |
| chr12:54,431,650–54,432,865 | 107.0 kb | Distal (>10kb) Multiome | 498 | |
| chr12:54,452,678–54,453,187 | 127.7 kb | Distal (>10kb) Multiome | 54 | |
| chr12:54,549,254–54,550,339 | 224.5 kb | Distal (>10kb) Multiome | 365 | |
| chr12:54,579,588–54,580,234 | 254.8 kb | Distal (>10kb) Multiome | 271 | |
| chr12:54,588,122–54,588,928 | 263.5 kb | Distal (>10kb) Multiome | 182 |
Genomic view of the COPZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.