The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for ITGA5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGA5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGA5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:54,125,925–54,126,686 | 293.0 kb | Distal (>10kb) Multiome | 244 | |
| chr12:54,159,055–54,159,510 | 259.9 kb | Distal (>10kb) Multiome | 263 | |
| chr12:54,188,672–54,189,215 | 230.2 kb | Distal (>10kb) Multiome | 529 | |
| chr12:54,214,692–54,215,229 | 204.3 kb | Distal (>10kb) Multiome | 646 | |
| chr12:54,216,935–54,217,348 | 202.1 kb | Distal (>10kb) Multiome | 450 | |
| chr12:54,217,640–54,218,303 | 201.1 kb | Distal (>10kb) Multiome | 212 | |
| chr12:54,259,188–54,260,497 | 159.5 kb | Distal (>10kb) Multiome | 573 | |
| chr12:54,279,361–54,281,440 | 138.6 kb | Distal (>10kb) Multiome | 1100 | |
| chr12:54,300,732–54,301,299 | 118.2 kb | Distal (>10kb) Multiome | 545 | |
| chr12:54,324,486–54,325,464 | 94.2 kb | Distal (>10kb) Multiome | 885 | |
| chr12:54,358,730–54,359,779 | 59.9 kb | Distal (>10kb) Multiome | 857 | |
| chr12:54,370,156–54,370,782 | 48.7 kb | Distal (>10kb) Multiome | 399 | |
| chr12:54,378,747–54,380,140 | 40.0 kb | Distal (>10kb) Multiome | 649 | |
| chr12:54,390,265–54,391,699 | 27.9 kb | Distal (>10kb) Multiome | 393 | |
| chr12:54,419,123–54,419,837 | 180 bp | At TSS Multiome | 441 | |
| chr12:54,428,323–54,428,613 | 9.1 kb | Proximal (<10kb) | 109 | |
| chr12:54,431,650–54,432,865 | 12.9 kb | Distal (>10kb) Multiome | 498 | |
| chr12:54,452,678–54,453,187 | 33.6 kb | Distal (>10kb) Multiome | 54 | |
| chr12:54,549,254–54,550,339 | 130.4 kb | Distal (>10kb) Multiome | 365 | |
| chr12:54,579,588–54,580,234 | 160.7 kb | Distal (>10kb) Multiome | 271 | |
| chr12:54,588,122–54,588,928 | 169.4 kb | Distal (>10kb) Multiome | 182 | |
| chr12:54,683,314–54,683,885 | 264.4 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the ITGA5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.