Enables histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Involved in several processes, including chromatin organization; regulation of cell division; and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of ATAC complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ZZZ3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZZZ3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZZZ3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:77,681,742–77,684,058 | 33 bp | At TSS Multiome | 1050 | |
| chr1:77,686,763–77,688,131 | 4.3 kb | Proximal (<10kb) Multiome | 208 | |
| chr1:77,758,895–77,760,199 | 76.4 kb | Distal (>10kb) Multiome | 856 | |
| chr1:77,779,465–77,780,294 | 96.3 kb | Distal (>10kb) Multiome | 779 | |
| chr1:77,888,069–77,889,521 | 205.3 kb | Distal (>10kb) Multiome | 648 | |
| chr1:77,906,727–77,907,344 | 223.6 kb | Distal (>10kb) Multiome | 128 | |
| chr1:77,978,065–77,980,001 | 295.8 kb | Distal (>10kb) Multiome | 993 |
Genomic view of the ZZZ3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.