This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for SMUG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMUG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMUG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:53,938,348–53,939,947 | 250.3 kb | Distal (>10kb) Multiome | 537 | |
| chr12:53,984,667–53,985,381 | 203.9 kb | Distal (>10kb) Multiome | 456 | |
| chr12:54,017,619–54,018,921 | 170.9 kb | Distal (>10kb) Multiome | 663 | |
| chr12:54,125,925–54,126,686 | 62.8 kb | Distal (>10kb) Multiome | 244 | |
| chr12:54,159,055–54,159,510 | 29.6 kb | Distal (>10kb) Multiome | 263 | |
| chr12:54,188,672–54,189,215 | 27 bp | At TSS Multiome | 529 | |
| chr12:54,191,565–54,191,886 | 2.6 kb | Proximal (<10kb) | 439 | |
| chr12:54,214,692–54,215,229 | 25.9 kb | Distal (>10kb) Multiome | 646 | |
| chr12:54,216,935–54,217,348 | 28.1 kb | Distal (>10kb) Multiome | 450 | |
| chr12:54,217,640–54,218,303 | 29.1 kb | Distal (>10kb) Multiome | 212 | |
| chr12:54,259,188–54,260,497 | 70.7 kb | Distal (>10kb) Multiome | 573 | |
| chr12:54,279,361–54,281,440 | 91.6 kb | Distal (>10kb) Multiome | 1100 | |
| chr12:54,300,732–54,301,299 | 112.1 kb | Distal (>10kb) Multiome | 545 | |
| chr12:54,324,486–54,325,464 | 136.0 kb | Distal (>10kb) Multiome | 885 | |
| chr12:54,358,730–54,359,779 | 170.3 kb | Distal (>10kb) Multiome | 857 | |
| chr12:54,370,156–54,370,782 | 181.5 kb | Distal (>10kb) Multiome | 399 | |
| chr12:54,378,747–54,380,140 | 190.3 kb | Distal (>10kb) Multiome | 649 | |
| chr12:54,390,265–54,391,699 | 202.4 kb | Distal (>10kb) Multiome | 393 | |
| chr12:54,419,123–54,419,837 | 230.4 kb | Distal (>10kb) Multiome | 441 | |
| chr12:54,431,650–54,432,865 | 243.2 kb | Distal (>10kb) Multiome | 498 | |
| chr12:54,452,678–54,453,187 | 263.9 kb | Distal (>10kb) Multiome | 54 |
Genomic view of the SMUG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.