chr3:183,263,894–183,264,916

chr3 : 183,263,894 – 183,264,916

1,022 bp 100 TFs 6 linked genes

This 1.0 kb open chromatin element is linked to 6 target genes and is bound by 100 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
B3GNT5		403 bp	At TSS	Proximity
LAMP3		101.5 kb	Distal	Multiome
MCF2L2		164.2 kb	Distal	Multiome
MCCC1		164.9 kb	Distal	Multiome
KLHL6		280.4 kb	Distal	Multiome
DCUN1D1		283.9 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

100 transcription factors

ChIP DU145 GSE47987.AR.DU145 233 bp overlap

ChIP DU145_ARQ6540X GSE47987.AR.DU145_ARQ6540X 228 bp overlap

ChIP DU145_FOXA1_ARQ6540X GSE47987.AR.DU145_FOXA1_ARQ6540X 218 bp overlap

ChIP PC-3_R1881 GSE54110.AR.PC-3_R1881 292 bp overlap

Motif DE_60h DE_60h-Alx1_MA0854.2 8 bp overlap

Motif DE_60h DE_60h-Alx4_MA0853.2 12 bp overlap

Arid3b 1 dataset

Motif DE_60h DE_60h-Arid3b_MA0601.2 7 bp overlap

Motif DE_60h DE_60h-Arx_MA0874.2 10 bp overlap

BARX1 1 dataset

Motif DE_60h DE_60h-BARX1_MA0875.2 6 bp overlap

ChIP SK-MEL-147 GSE94488.BRD2.SK-MEL-147 260 bp overlap

BRD4 2 datasets

ChIP COLO-205 GSE73319.BRD4.COLO-205 235 bp overlap

ChIP SW480 GSE110473.BRD4.SW480 292 bp overlap

Motif DE_60h DE_60h-BSX_MA0876.2 6 bp overlap

CTCF 3 datasets

Motif DE_48h DE_48h-CTCF_MA0139.2 15 bp overlap

Motif DE_60h DE_60h-CTCF_MA0139.2 15 bp overlap

Motif DE_72h DE_72h-CTCF_MA0139.2 15 bp overlap

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

Motif DE_60h DE_60h-DLX1_MA0879.3 6 bp overlap

Motif DE_60h DE_60h-DLX6_MA0882.2 6 bp overlap

DMRTC2 1 dataset

Motif DE_60h DE_60h-DMRTC2_MA1479.2 11 bp overlap

Motif DE_60h DE_60h-Dlx3_MA0880.2 6 bp overlap

Motif DE_60h DE_60h-Dlx4_MA0881.2 6 bp overlap

ChIP RWPE-1 GSE114241.EHF.RWPE-1 136 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 612 bp overlap

ChIP HCT-116_A7A GSE152144.FOS.HCT-116_A7A 287 bp overlap

ChIP HCT-116_A7A GSE152144.FOS.HCT-116_A7A 65 bp overlap

FOS::JUND 2 datasets

Motif DE_48h DE_48h-FOSJUND_MA1141.2 9 bp overlap

Motif DE_72h DE_72h-FOSJUND_MA1141.2 9 bp overlap

FOSL1::JUN 2 datasets

Motif DE_48h DE_48h-FOSL1JUN_MA1128.2 9 bp overlap

Motif DE_72h DE_72h-FOSL1JUN_MA1128.2 9 bp overlap

FOSL1::JUNB 2 datasets

Motif DE_48h DE_48h-FOSL1JUNB_MA1137.2 9 bp overlap

Motif DE_72h DE_72h-FOSL1JUNB_MA1137.2 9 bp overlap

FOXA2 5 datasets

ChIP DE DE-FOXA2-1 754 bp overlap

ChIP DE DE-FOXA2-2 745 bp overlap

ChIP PANC-1 GSE119930.FOXA2.PANC-1 324 bp overlap

ChIP PANC-1_EV GSE119930.FOXA2.PANC-1_EV 340 bp overlap

ChIP PANC-1_HNF1B-OE GSE119930.FOXA2.PANC-1_HNF1B-OE 385 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 791 bp overlap

ChIP DE DE-GATA4-2 844 bp overlap

ChIP foregut GSE117136.GATA4.foregut 533 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 485 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 804 bp overlap

ChIP DE DE-GATA6-2 879 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 394 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 448 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 462 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 585 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 640 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 551 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 504 bp overlap

ChIP foregut GSE117136.GATA6.foregut 342 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 292 bp overlap

Motif DE_60h DE_60h-GBX2_MA0890.2 6 bp overlap

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

GSC2 3 datasets

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

ChIP K-562 ENCSR197ALX.HDGF.K-562 175 bp overlap

HESX1 1 dataset

Motif DE_60h DE_60h-HESX1_MA0894.2 6 bp overlap

HMBOX1 2 datasets

ChIP K-562 ENCSR757IIU.HMBOX1.K-562 276 bp overlap

ChIP K562 ENCFF055GAZ 531 bp overlap

HOXA7 1 dataset

Motif DE_60h DE_60h-HOXA7_MA1498.3 6 bp overlap

HOXC13 2 datasets

Motif DE_48h DE_48h-HOXC13_MA0907.2 9 bp overlap

Motif DE_72h DE_72h-HOXC13_MA0907.2 9 bp overlap

Motif DE_60h DE_60h-Hmx1_MA0896.2 9 bp overlap

Motif DE_60h DE_60h-Hmx3_MA0898.2 9 bp overlap

Hnf1A 3 datasets

Motif DE_48h DE_48h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_72h DE_72h-Hnf1A_MA1991.2 10 bp overlap

INSM1 3 datasets

Motif DE_48h DE_48h-INSM1_MA0155.1 12 bp overlap

Motif DE_60h DE_60h-INSM1_MA0155.1 12 bp overlap

Motif DE_72h DE_72h-INSM1_MA0155.1 12 bp overlap

ChIP keratinocyte_DOX GSE135677.IRF2.keratinocyte_DOX 219 bp overlap

IRF2BP2 1 dataset

ChIP HEK293 GSE124636.IRF2BP2.HEK293 391 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 314 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 307 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 475 bp overlap

Motif DE_48h DE_48h-Jun_MA0489.3 8 bp overlap

Motif DE_72h DE_72h-Jun_MA0489.3 8 bp overlap

Motif DE_60h DE_60h-LBX2_MA0699.2 6 bp overlap

Motif DE_60h DE_60h-LHX2_MA0700.3 6 bp overlap

MAFF 2 datasets

Motif DE_48h DE_48h-MAFF_MA0495.4 11 bp overlap

Motif DE_72h DE_72h-MAFF_MA0495.4 11 bp overlap

ChIP MCF-7_SHRARS GSE60270.MED1.MCF-7_SHRARS 119 bp overlap

MEIS1 3 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MSX1_MA0666.3 6 bp overlap

Motif DE_60h DE_60h-MSX2_MA0708.3 6 bp overlap

MXI1 3 datasets

Motif DE_48h DE_48h-MXI1_MA1108.3 6 bp overlap

Motif DE_60h DE_60h-MXI1_MA1108.3 6 bp overlap

Motif DE_72h DE_72h-MXI1_MA1108.3 6 bp overlap

Motif DE_60h DE_60h-MYB_MA0100.4 6 bp overlap

ChIP MYCN-3_low GSE83317.MYCN.MYCN-3_low 124 bp overlap

Motif DE_60h DE_60h-Msx3_MA0709.2 6 bp overlap

NANOG 3 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 538 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 435 bp overlap

ChIP hESC GSE20650.NANOG.hESC 151 bp overlap

NR3C1 8 datasets

ChIP A-549 ENCSR000BHF.NR3C1.A-549 230 bp overlap

ChIP A-549 ENCSR000BJR.NR3C1.A-549 109 bp overlap

ChIP MCF-10A_EGF_DEX_60min GSE102355.NR3C1.MCF-10A_EGF_DEX_60min 226 bp overlap

ChIP MDA-MB-231 GSE152203.NR3C1.MDA-MB-231 320 bp overlap

ChIP SUM159PT GSE152203.NR3C1.SUM159PT 237 bp overlap

ChIP U2OS_GLUCC ERP007081.NR3C1.U2OS_GLUCC 95 bp overlap

ChIP U2OS_SHHIC5 GSE65847.NR3C1.U2OS_SHHIC5 378 bp overlap

ChIP U2OS_SHNS GSE65847.NR3C1.U2OS_SHNS 211 bp overlap

Nobox 1 dataset

Motif DE_60h DE_60h-Nobox_MA0125.2 6 bp overlap

OTX1 3 datasets

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

ChIP AB32 GSE31129.PGR.AB32 321 bp overlap

Motif DE_48h DE_48h-PGR_MA2327.1 9 bp overlap

Motif DE_60h DE_60h-PGR_MA2327.1 9 bp overlap

Motif DE_72h DE_72h-PGR_MA2327.1 9 bp overlap

PITX1 3 datasets

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap

PITX3 3 datasets

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

POU5F1 1 dataset

ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 289 bp overlap

PRDM6 3 datasets

ChIP HEK293 ENCFF283AJL 176 bp overlap

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 440 bp overlap

ChIP HEK293 GSE76494.PRDM6.HEK293 294 bp overlap

PROX1 1 dataset

ChIP SW480 GSE60390.PROX1.SW480 239 bp overlap

Prdm15 3 datasets

Motif DE_48h DE_48h-Prdm15_MA1616.2 11 bp overlap

Motif DE_60h DE_60h-Prdm15_MA1616.2 11 bp overlap

Motif DE_72h DE_72h-Prdm15_MA1616.2 11 bp overlap

Motif DE_60h DE_60h-RAX_MA0718.2 6 bp overlap

RBPJ 5 datasets

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap

RELA 2 datasets

ChIP SW480_16h_TNFa GSE102796.RELA.SW480_16h_TNFa 155 bp overlap

ChIP aortic-endothelial-cell_IL1B_D49 GSE139377.RELA.aortic-endothelial-cell_IL1B_D49 168 bp overlap

RHOXF1 3 datasets

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

RUNX1 1 dataset

ChIP Jurkat GSE68976.RUNX1.Jurkat 173 bp overlap

SCRT1 2 datasets

ChIP HEK293 ENCFF513YVP 417 bp overlap

ChIP HEK293 ENCSR605MGM.SCRT1.HEK293 387 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 907 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 446 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 550 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 312 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 420 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 598 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 531 bp overlap

SMARCA4 1 dataset

ChIP NPC_K755R-siAP GSE122631.SMARCA4.NPC_K755R-siAP 207 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 194 bp overlap

ChIP peripheral-blood-neutrophil_Ecoli-1 GSE126755.SMC3.peripheral-blood-neutrophil_Ecoli-1 286 bp overlap

SOX13 3 datasets

Motif DE_48h DE_48h-SOX13_MA1120.2 7 bp overlap

Motif DE_60h DE_60h-SOX13_MA1120.2 7 bp overlap

Motif DE_72h DE_72h-SOX13_MA1120.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 367 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 367 bp overlap

SOX2 7 datasets

Motif DE_48h DE_48h-SOX2_MA0143.5 7 bp overlap

Motif DE_60h DE_60h-SOX2_MA0143.5 7 bp overlap

Motif DE_72h DE_72h-SOX2_MA0143.5 7 bp overlap

ChIP HNSC GSE69479.SOX2.HNSC 551 bp overlap

ChIP LK2 GSE137459.SOX2.LK2 581 bp overlap

ChIP LK2_DNp63 GSE137459.SOX2.LK2_DNp63 371 bp overlap

ChIP LK2_GFP GSE137459.SOX2.LK2_GFP 569 bp overlap

SOX4 3 datasets

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap

Motif DE_72h DE_72h-SOX4_MA0867.3 8 bp overlap

SOX8 3 datasets

Motif DE_48h DE_48h-SOX8_MA0868.3 7 bp overlap

Motif DE_60h DE_60h-SOX8_MA0868.3 7 bp overlap

Motif DE_72h DE_72h-SOX8_MA0868.3 7 bp overlap

SOX9 3 datasets

Motif DE_48h DE_48h-SOX9_MA0077.2 8 bp overlap

Motif DE_60h DE_60h-SOX9_MA0077.2 8 bp overlap

Motif DE_72h DE_72h-SOX9_MA0077.2 8 bp overlap

ChIP HEK293 ENCSR468IJT.SP7.HEK293 239 bp overlap

Motif DE_48h DE_48h-SP8_MA0747.2 11 bp overlap

Motif DE_72h DE_72h-SP8_MA0747.2 11 bp overlap

SREBP2 2 datasets

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 233 bp overlap

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 82 bp overlap

Sox17 3 datasets

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Motif DE_60h DE_60h-Sox17_MA0078.3 10 bp overlap

Motif DE_72h DE_72h-Sox17_MA0078.3 10 bp overlap

Sox3 3 datasets

Motif DE_48h DE_48h-Sox3_MA0514.3 7 bp overlap

Motif DE_60h DE_60h-Sox3_MA0514.3 7 bp overlap

Motif DE_72h DE_72h-Sox3_MA0514.3 7 bp overlap

Sox5 3 datasets

Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap

Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap

Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap

Sox7 3 datasets

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap

Motif DE_72h DE_72h-Sox7_MA2095.1 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 405 bp overlap

TCF7L2 3 datasets

Motif DE_48h DE_48h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_60h DE_60h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_72h DE_72h-TCF7L2_MA0523.2 9 bp overlap

ChIP SW480_0h_TNFa GSE102796.TP53.SW480_0h_TNFa 300 bp overlap

Thap11 2 datasets

Motif DE_48h DE_48h-Thap11_MA1573.2 14 bp overlap

Motif DE_72h DE_72h-Thap11_MA1573.2 14 bp overlap

ZBTB18 1 dataset

Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap

ZBTB32 2 datasets

Motif DE_48h DE_48h-ZBTB32_MA1580.1 10 bp overlap

Motif DE_72h DE_72h-ZBTB32_MA1580.1 10 bp overlap

ZBTB42 1 dataset

ChIP HEK293 GSE76494.ZBTB42.HEK293 163 bp overlap

ChIP HEK293 ENCFF033NQQ 342 bp overlap

ZNF366 2 datasets

ChIP HEK293 ENCFF799ATK 140 bp overlap

ChIP HEK293 ENCSR106EBH.ZNF366.HEK293 150 bp overlap

ZNF660 1 dataset

ChIP HEK293 ENCSR283DOU.ZNF660.HEK293 284 bp overlap

ZNF708 2 datasets

Motif DE_48h DE_48h-ZNF708_MA1730.2 9 bp overlap

Motif DE_72h DE_72h-ZNF708_MA1730.2 9 bp overlap