Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MCF2L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCF2L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCF2L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:183,122,434–183,123,139 | 305.8 kb | Distal (>10kb) Multiome HiCAR | 170 | |
| chr3:183,162,396–183,163,145 | 265.9 kb | Distal (>10kb) Multiome | 469 | |
| chr3:183,178,821–183,179,763 | 249.4 kb | Distal (>10kb) Multiome | 364 | |
| chr3:183,253,013–183,254,897 | 174.3 kb | Distal (>10kb) Multiome | 529 | |
| chr3:183,263,894–183,264,916 | 164.2 kb | Distal (>10kb) Multiome | 100 | |
| chr3:183,265,177–183,265,699 | 163.2 kb | Distal (>10kb) Multiome | 111 | |
| chr3:183,428,041–183,429,327 | 150 bp | At TSS Multiome | 572 | |
| chr3:183,430,650–183,431,149 | 2.0 kb | Proximal (<10kb) | 49 | |
| chr3:183,431,471–183,431,661 | 2.9 kb | Proximal (<10kb) | 8 | |
| chr3:183,433,737–183,435,984 | 5.9 kb | Proximal (<10kb) Multiome | 282 | |
| chr3:183,447,193–183,447,991 | 18.9 kb | Distal (>10kb) Multiome | 926 | |
| chr3:183,544,658–183,545,145 | 116.3 kb | Distal (>10kb) Multiome | 164 | |
| chr3:183,635,238–183,637,215 | 206.9 kb | Distal (>10kb) Multiome | 923 | |
| chr3:183,697,518–183,698,578 | 269.3 kb | Distal (>10kb) Multiome | 787 |
Genomic view of the MCF2L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.