This gene encodes lysosome-associated membrane glycoprotein 3, a type 1 integral membrane protein that belongs to a family of lysosome associated membrane proteins which form part of the glycoconjugate coat present on the inside of the lysosomal membrane. It is predominantly expressed in mature dendritic cells and serves as a marker of dendritic cell maturation. The encoded protein localizes primarily to late endosomes/lysosomes and the MHC class II compartment, where it contributes to antigen processing and presentation during adaptive immune responses. The expression of this gene is inducible under hypoxic conditions via hypoxia-inducible factor 1-alpha signaling. In cancer, this gene is frequently overexpressed and is associated with tumor progression, metastasis, therapy resistance, and poor clinical prognosis in multiple malignancies including breast, cervical, and ovarian cancers. [provided by RefSeq, Feb 2026]
Transcription factors with Perturb-seq knockdown data for LAMP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAMP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAMP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:182,979,737–182,981,250 | 182.3 kb | Distal (>10kb) Multiome | 562 | |
| chr3:183,009,852–183,010,416 | 152.9 kb | Distal (>10kb) Multiome | 225 | |
| chr3:183,098,895–183,099,840 | 63.3 kb | Distal (>10kb) Multiome | 915 | |
| chr3:183,113,896–183,115,137 | 48.6 kb | Distal (>10kb) Multiome | 114 | |
| chr3:183,115,986–183,116,533 | 46.7 kb | Distal (>10kb) Multiome | 294 | |
| chr3:183,122,434–183,123,139 | 40.1 kb | Distal (>10kb) Multiome | 170 | |
| chr3:183,162,396–183,163,145 | 131 bp | At TSS Multiome | 469 | |
| chr3:183,164,534–183,164,785 | 1.7 kb | Proximal (<10kb) | 13 | |
| chr3:183,178,821–183,179,763 | 16.3 kb | Distal (>10kb) Multiome | 364 | |
| chr3:183,263,894–183,264,916 | 101.5 kb | Distal (>10kb) Multiome | 100 | |
| chr3:183,428,041–183,429,327 | 265.9 kb | Distal (>10kb) Multiome | 572 | |
| chr3:183,433,737–183,435,984 | 271.7 kb | Distal (>10kb) Multiome | 282 | |
| chr3:183,447,193–183,447,991 | 284.6 kb | Distal (>10kb) Multiome | 926 |
Genomic view of the LAMP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.