This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for B3GNT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B3GNT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B3GNT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:182,979,737–182,981,250 | 274.1 kb | Distal (>10kb) Multiome | 562 | |
| chr3:183,009,852–183,010,416 | 244.6 kb | Distal (>10kb) Multiome | 225 | |
| chr3:183,098,895–183,099,840 | 155.0 kb | Distal (>10kb) Multiome | 915 | |
| chr3:183,113,896–183,115,137 | 140.4 kb | Distal (>10kb) Multiome | 114 | |
| chr3:183,115,986–183,116,533 | 138.4 kb | Distal (>10kb) Multiome | 294 | |
| chr3:183,122,434–183,123,139 | 131.8 kb | Distal (>10kb) Multiome | 170 | |
| chr3:183,162,396–183,163,145 | 91.9 kb | Distal (>10kb) Multiome | 469 | |
| chr3:183,178,821–183,179,763 | 75.4 kb | Distal (>10kb) Multiome | 364 | |
| chr3:183,248,964–183,249,665 | 4.1 kb | Proximal (<10kb) | 37 | |
| chr3:183,250,632–183,251,003 | 2.8 kb | Proximal (<10kb) | 14 | |
| chr3:183,253,013–183,254,897 | 289 bp | At TSS Multiome | 529 | |
| chr3:183,255,430–183,255,653 | 1.6 kb | Proximal (<10kb) | 138 | |
| chr3:183,263,894–183,264,916 | 9.8 kb | Proximal (<10kb) Multiome | 100 | |
| chr3:183,265,177–183,265,699 | 10.8 kb | Distal (>10kb) Multiome | 111 | |
| chr3:183,266,034–183,266,316 | 714 bp | At TSS | 181 | |
| chr3:183,267,968–183,268,884 | 2.6 kb | Proximal (<10kb) | 118 | |
| chr3:183,428,041–183,429,327 | 174.1 kb | Distal (>10kb) Multiome | 572 | |
| chr3:183,433,737–183,435,984 | 179.9 kb | Distal (>10kb) Multiome | 282 | |
| chr3:183,447,193–183,447,991 | 192.9 kb | Distal (>10kb) Multiome | 926 | |
| chr3:183,544,658–183,545,145 | 290.3 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the B3GNT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.