This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for KLHL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:183,263,894–183,264,916 | 280.4 kb | Distal (>10kb) Multiome | 100 | |
| chr3:183,428,041–183,429,327 | 116.0 kb | Distal (>10kb) Multiome | 572 | |
| chr3:183,433,737–183,435,984 | 110.2 kb | Distal (>10kb) Multiome | 282 | |
| chr3:183,447,193–183,447,991 | 97.3 kb | Distal (>10kb) Multiome | 926 | |
| chr3:183,544,658–183,545,145 | 122 bp | At TSS Multiome | 164 | |
| chr3:183,635,238–183,637,215 | 90.7 kb | Distal (>10kb) Multiome | 923 | |
| chr3:183,697,518–183,698,578 | 153.1 kb | Distal (>10kb) Multiome | 787 | |
| chr3:183,824,588–183,826,123 | 280.9 kb | Distal (>10kb) Multiome | 467 |
Genomic view of the KLHL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.