chr18:49,527,826–49,528,357

chr18 : 49,527,826 – 49,528,357

531 bp 61 TFs 6 linked genes

This 531 bp open chromatin element is linked to 6 target genes and is bound by 61 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
LIPG		32.5 kb	Distal	Multiome
RPL17		35.7 kb	Distal	Multiome
C18orf32		40.9 kb	Distal	Multiome
DYM		67.5 kb	Distal	Multiome
ACAA2		285.4 kb	Distal	Multiome+HiCAR
SNHG22		285.9 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

61 transcription factors

ARID1B 2 datasets

ChIP K-562 ENCSR822CCM.ARID1B.K-562 427 bp overlap

ChIP K562 ENCFF938UXQ 253 bp overlap

ASXL3 1 dataset

ChIP NCI-H1963_Ab1 GSE145028.ASXL3.NCI-H1963_Ab1 264 bp overlap

ATF3 3 datasets

ChIP K-562 ENCSR028UIU.ATF3.K-562 368 bp overlap

ChIP K-562 ENCSR632DCH.ATF3.K-562 265 bp overlap

ChIP K562 ENCFF921JQW 531 bp overlap

BACH1 2 datasets

ChIP H1 ENCFF282VDB 321 bp overlap

ChIP WA01 ENCSR000EBQ.BACH1.WA01 313 bp overlap

BCL11A 1 dataset

ChIP HUDEP-2_90min GSE104676.BCL11A.HUDEP-2_90min 68 bp overlap

BRD3 2 datasets

ChIP H-1_DE GSE126661.BRD3.H-1_DE 198 bp overlap

ChIP K-562_DMSO GSE138084.BRD3.K-562_DMSO 262 bp overlap

BRD4 3 datasets

ChIP NCI-H1963 GSE145028.BRD4.NCI-H1963 249 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 531 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 317 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 275 bp overlap

ChIP K562 ENCFF673OEZ 400 bp overlap

CCNT2 1 dataset

ChIP K-562 ENCSR000DOA.CCNT2.K-562 240 bp overlap

CTBP1 2 datasets

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 384 bp overlap

ChIP K562 ENCFF403WPG 441 bp overlap

CXXC5 1 dataset

ChIP K562 ENCFF497CZN 475 bp overlap

DPF2 3 datasets

ChIP K-562 ENCSR219BXP.DPF2.K-562 363 bp overlap

ChIP K562 ENCFF739JDE 434 bp overlap

ChIP K562 ENCFF775HUO 252 bp overlap

ChIP K562 ENCFF511ZZZ 227 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 205 bp overlap

FOSL1 2 datasets

ChIP BT-549 GSE46166.FOSL1.BT-549 332 bp overlap

ChIP K562 ENCFF455MKD 531 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 390 bp overlap

ChIP DE DE-FOXA2-2 189 bp overlap

GATA1 3 datasets

ChIP CD34_Day7_30min GSE104676.GATA1.CD34_Day7_30min 55 bp overlap

ChIP CD34_ERYTH_BIO GSE29194.GATA1.CD34_ERYTH_BIO 177 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 243 bp overlap

GATA2 2 datasets

ChIP K562 ENCFF544PCK 251 bp overlap

ChIP TF1 GSE73207.GATA2.TF1 275 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 522 bp overlap

ChIP DE DE-GATA4-2 531 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 238 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 375 bp overlap

GATA6 12 datasets

ChIP AGS GSE51705.GATA6.AGS 150 bp overlap

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 166 bp overlap

ChIP DE DE-GATA6-1 529 bp overlap

ChIP DE DE-GATA6-2 531 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 435 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 465 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 531 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 496 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 531 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 531 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 463 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 432 bp overlap

HDAC1 2 datasets

ChIP K-562 ENCSR387UWP.HDAC1.K-562 285 bp overlap

ChIP K562 ENCFF968WBH 469 bp overlap

HDAC2 1 dataset

ChIP K-562 ENCSR893WSB.HDAC2.K-562 316 bp overlap

ChIP Hep-G2 ENCSR528PSI.HLF.Hep-G2 144 bp overlap

ChIP HepG2 ENCFF854JLR 245 bp overlap

HMGN3 1 dataset

ChIP K-562 ENCSR000DOB.HMGN3.K-562 162 bp overlap

IKZF1 1 dataset

ChIP K-562 ENCSR395HWC.IKZF1.K-562 479 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 455 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 279 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 335 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 518 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 460 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 467 bp overlap

JUND 3 datasets

ChIP K-562 ENCSR000EGN.JUND.K-562 150 bp overlap

ChIP K562 ENCFF336RCR 435 bp overlap

ChIP K562 ENCFF830LVJ 281 bp overlap

KMT2A 1 dataset

ChIP THP-1 GSE79899.KMT2A.THP-1 135 bp overlap

ChIP K562 ENCFF071YKK 281 bp overlap

MAFG 2 datasets

ChIP K-562 ENCSR818DQV.MAFG.K-562 406 bp overlap

ChIP K562 ENCFF455EEO 181 bp overlap

MAFK 3 datasets

ChIP H1 ENCFF854XWE 285 bp overlap

ChIP K562 ENCFF380WHM 281 bp overlap

ChIP WA01 ENCSR000EBS.MAFK.WA01 309 bp overlap

ChIP K-562 ENCSR411UYA.MTA2.K-562 218 bp overlap

ChIP CD34 GSE85488.MYC.CD34 127 bp overlap

NFE2 4 datasets

ChIP K-562 ENCSR000FCC.NFE2.K-562 398 bp overlap

ChIP K-562 ENCSR552YGL.NFE2.K-562 449 bp overlap

ChIP K562 ENCFF047YKA 233 bp overlap

ChIP K562 ENCFF163BSI 135 bp overlap

NFE2L2 1 dataset

ChIP K-562 ENCSR485GKE.NFE2L2.K-562 223 bp overlap

NOTCH3 1 dataset

ChIP TALL-1_GSI GSE104261.NOTCH3.TALL-1_GSI 135 bp overlap

ChIP HeLa-S3 GSE108856.NRF1.HeLa-S3 275 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 381 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 270 bp overlap

RCOR1 1 dataset

ChIP K562 ENCFF216EEJ 297 bp overlap

RNF2 3 datasets

ChIP K562 ENCFF653BQJ 518 bp overlap

ChIP K562 ENCFF653BQJ 308 bp overlap

ChIP fibroblast GSE139053.RNF2.fibroblast 360 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 173 bp overlap

SMAD2-3 4 datasets

ChIP HGrC1_WT GSE138496.SMAD2-3.HGrC1_WT 120 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 481 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 438 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 531 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 375 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 419 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 436 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 460 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 438 bp overlap

SMARCA4 2 datasets

ChIP K-562 ENCSR587OQL.SMARCA4.K-562 373 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 169 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 221 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 262 bp overlap

SMARCE1 2 datasets

ChIP K-562 ENCSR157TCS.SMARCE1.K-562 411 bp overlap

ChIP K562 ENCFF690CFF 176 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 384 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 479 bp overlap

SOX6 2 datasets

ChIP K-562 ENCSR788RSW.SOX6.K-562 405 bp overlap

ChIP K562 ENCFF059YCJ 239 bp overlap

ChIP K-562 ENCSR000EHB.TAL1.K-562 133 bp overlap

TCF12 1 dataset

ChIP Ishikawa ENCSR000BUV.TCF12.Ishikawa 173 bp overlap

ChIP K-562 ENCSR970OJY.TCF3.K-562 144 bp overlap

ChIP Ishikawa ENCSR000BSY.YY1.Ishikawa 91 bp overlap

ZBTB7A 2 datasets

ChIP HUDEP-2 GSE103445.ZBTB7A.HUDEP-2 356 bp overlap

ChIP Ishikawa ENCSR000BSZ.ZBTB7A.Ishikawa 184 bp overlap

ZEB2 4 datasets

ChIP K-562 ENCSR322CFO.ZEB2.K-562 428 bp overlap

ChIP K-562 ENCSR004GKA.ZEB2.K-562 415 bp overlap

ChIP K562 ENCFF795CMH 342 bp overlap

ChIP K562 ENCFF975RXS 246 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 417 bp overlap

ZNF335 2 datasets

ChIP HEK293 ENCFF784SLD 531 bp overlap

ChIP HEK293 ENCSR328SUD.ZNF335.HEK293 531 bp overlap

ZNF398 2 datasets

ChIP HEK293 ENCFF184XEW 310 bp overlap

ChIP HEK293 ENCSR676ZEF.ZNF398.HEK293 268 bp overlap

ZNF467 1 dataset

ChIP HEK293 GSE76494.ZNF467.HEK293 100 bp overlap

ZNF692 1 dataset

ChIP HEK293 ENCSR418MKG.ZNF692.HEK293 288 bp overlap