Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for RPL17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:49,252,346–49,252,812 | 240.0 kb | Distal (>10kb) Multiome | 15 | |
| chr18:49,460,079–49,460,928 | 31.8 kb | Distal (>10kb) Multiome | 871 | |
| chr18:49,486,741–49,487,756 | 5.2 kb | Proximal (<10kb) Multiome | 980 | |
| chr18:49,491,896–49,492,680 | 41 bp | At TSS Multiome | 825 | |
| chr18:49,499,108–49,499,390 | 6.6 kb | Proximal (<10kb) | 40 | |
| chr18:49,500,180–49,500,915 | 8.1 kb | Proximal (<10kb) Multiome | 124 | |
| chr18:49,527,826–49,528,357 | 35.7 kb | Distal (>10kb) Multiome | 61 | |
| chr18:49,560,867–49,562,777 | 69.4 kb | Distal (>10kb) Multiome | 537 | |
| chr18:49,613,011–49,613,628 | 120.8 kb | Distal (>10kb) Multiome | 220 | |
| chr18:49,723,619–49,724,545 | 231.4 kb | Distal (>10kb) Multiome HiCAR | 344 | |
| chr18:49,725,786–49,726,901 | 233.8 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr18:49,759,484–49,760,451 | 267.6 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr18:49,813,360–49,814,537 | 321.4 kb | Distal (>10kb) Multiome HiCAR | 858 |
Genomic view of the RPL17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.