The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for CCNT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:134,717,803–134,719,682 | 199.7 kb | Distal (>10kb) Multiome | 356 | |
| chr2:134,751,756–134,752,551 | 166.7 kb | Distal (>10kb) Multiome | 87 | |
| chr2:134,771,271–134,772,068 | 147.3 kb | Distal (>10kb) Multiome HiCAR | 67 | |
| chr2:134,772,446–134,773,111 | 145.9 kb | Distal (>10kb) Multiome HiCAR | 73 | |
| chr2:134,773,347–134,774,561 | 144.8 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr2:134,774,748–134,775,767 | 143.6 kb | Distal (>10kb) Multiome HiCAR | 312 | |
| chr2:134,917,525–134,919,689 | 229 bp | At TSS Multiome | 1062 | |
| chr2:135,051,922–135,052,757 | 133.5 kb | Distal (>10kb) Multiome | 803 | |
| chr2:135,110,158–135,110,677 | 191.7 kb | Distal (>10kb) Multiome | 68 |
Genomic view of the CCNT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.