ACAA2

acetyl-CoA acyltransferase 2 | DSAEC

The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.11

Biological processes 24 terms

RNA binding (GO:0003723)acetyl-CoA C-acetyltransferase activity (GO:0003985)acetyl-CoA C-acetyltransferase activity (GO:0003985)acetyl-CoA C-acetyltransferase activity (GO:0003985)acetyl-CoA C-acyltransferase activity (GO:0003988)acetyl-CoA C-acyltransferase activity (GO:0003988)acetyl-CoA C-acyltransferase activity (GO:0003988)acetyl-CoA hydrolase activity (GO:0003986)acyltransferase activity (GO:0016746)acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747)cellular response to hypoxia (GO:0071456)cholesterol biosynthetic process (GO:0006695)fatty acid beta-oxidation (GO:0006635)fatty acid beta-oxidation (GO:0006635)fatty acyl-CoA hydrolase activity (GO:0047617)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902109)negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901029)protein binding (GO:0005515)

Expression (TPM)

TFs regulating ACAA2 0 TFs

Transcription factors with Perturb-seq knockdown data for ACAA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACAA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ACAA2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACAA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr18:49,491,896–49,492,680	321.1 kb	Distal (>10kb) Multiome HiCAR	825
chr18:49,527,826–49,528,357	285.4 kb	Distal (>10kb) Multiome HiCAR	61
chr18:49,560,867–49,562,777	251.6 kb	Distal (>10kb) Multiome	537
chr18:49,613,011–49,613,628	200.2 kb	Distal (>10kb) Multiome	220
chr18:49,723,619–49,724,545	89.6 kb	Distal (>10kb) Multiome	344
chr18:49,725,786–49,726,901	87.3 kb	Distal (>10kb) Multiome	248
chr18:49,759,484–49,760,451	53.5 kb	Distal (>10kb) Multiome	147
chr18:49,813,360–49,814,537	379 bp	At TSS Multiome	858
chr18:49,905,054–49,905,920	91.9 kb	Distal (>10kb) Multiome	75
chr18:49,911,085–49,912,315	98.1 kb	Distal (>10kb) Multiome	185
chr18:49,959,032–49,959,704	145.9 kb	Distal (>10kb) Multiome	100

Genome Browser

Genomic view of the ACAA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.