Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C18orf32. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C18orf32 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C18orf32, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:49,252,346–49,252,812 | 234.7 kb | Distal (>10kb) Multiome | 15 | |
| chr18:49,460,079–49,460,928 | 26.6 kb | Distal (>10kb) Multiome | 871 | |
| chr18:49,486,741–49,487,756 | 10 bp | At TSS Multiome | 980 | |
| chr18:49,491,896–49,492,680 | 5.2 kb | Proximal (<10kb) Multiome | 825 | |
| chr18:49,500,180–49,500,915 | 13.4 kb | Distal (>10kb) Multiome | 124 | |
| chr18:49,527,826–49,528,357 | 40.9 kb | Distal (>10kb) Multiome | 61 | |
| chr18:49,560,867–49,562,777 | 74.7 kb | Distal (>10kb) Multiome | 537 | |
| chr18:49,613,011–49,613,628 | 126.0 kb | Distal (>10kb) Multiome | 220 | |
| chr18:49,723,619–49,724,545 | 236.7 kb | Distal (>10kb) Multiome | 344 | |
| chr18:49,725,786–49,726,901 | 239.0 kb | Distal (>10kb) Multiome | 248 | |
| chr18:49,759,484–49,760,451 | 272.8 kb | Distal (>10kb) Multiome | 147 |
Genomic view of the C18orf32 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.