chr16 : 13,633,353 – 13,634,315

962 bp 81 TFs 1 linked gene

This 962 bp open chromatin element is linked to ERCC4 and is bound by 81 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
ERCC4		286.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

81 transcription factors

ARID1A 2 datasets

ChIP RMG-I GSE104545.ARID1A.RMG-I 383 bp overlap

ChIP RMG-I GSE120058.ARID1A.RMG-I 419 bp overlap

ATF7 1 dataset

ChIP GM12878 ENCSR014YCR.ATF7.GM12878 223 bp overlap

Arid3a 1 dataset

Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap

Arid5a 1 dataset

Motif DE_72h DE_72h-Arid5a_MA0602.2 8 bp overlap

BATF 1 dataset

ChIP GM12878 ENCFF954REE 62 bp overlap

BCL11A 2 datasets

ChIP GM12878 ENCFF717YPR 237 bp overlap

ChIP GM12878 ENCSR000BHA.BCL11A.GM12878 264 bp overlap

BHLHE40 2 datasets

ChIP GM12878 ENCFF521IZR 335 bp overlap

ChIP GM12878 ENCSR987MTA.BHLHE40.GM12878 289 bp overlap

CHD4 1 dataset

ChIP pre-B-cell GSE107886.CHD4.pre-B-cell 182 bp overlap

DACH1 2 datasets

ChIP K-562 ENCSR030TJP.DACH1.K-562 95 bp overlap

ChIP K562 ENCFF574LOW 66 bp overlap

DPF2 1 dataset

ChIP GM12878 ENCSR509FWH.DPF2.GM12878 362 bp overlap

DUX4 1 dataset

Motif DE_72h DE_72h-DUX4_MA0468.1 11 bp overlap

EGR4 2 datasets

Motif DE_60h DE_60h-EGR4_MA0733.2 11 bp overlap

Motif DE_72h DE_72h-EGR4_MA0733.2 11 bp overlap

ESR1 1 dataset

ChIP MCF-7_E2_talen GSE94493.ESR1.MCF-7_E2_talen 104 bp overlap

FEZF2 2 datasets

Motif DE_60h DE_60h-FEZF2_MA2341.1 8 bp overlap

Motif DE_72h DE_72h-FEZF2_MA2341.1 8 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 630 bp overlap

ChIP DE DE-FOXA2-2 676 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 590 bp overlap

ChIP DE DE-GATA4-2 894 bp overlap

ChIP foregut GSE117136.GATA4.foregut 537 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 241 bp overlap

GATA5 1 dataset

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 603 bp overlap

ChIP DE DE-GATA6-2 860 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 632 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 767 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 859 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 706 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 789 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 905 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 468 bp overlap

ChIP foregut GSE117136.GATA6.foregut 464 bp overlap

GMEB1 1 dataset

ChIP K562 ENCFF705LHX 181 bp overlap

Gli1 2 datasets

Motif DE_60h DE_60h-Gli1_MA1990.2 10 bp overlap

Motif DE_72h DE_72h-Gli1_MA1990.2 10 bp overlap

Gli2 2 datasets

Motif DE_60h DE_60h-Gli2_MA0734.4 9 bp overlap

Motif DE_72h DE_72h-Gli2_MA0734.4 9 bp overlap

HDAC2 1 dataset

ChIP pre-B-cell GSE107886.HDAC2.pre-B-cell 176 bp overlap

HLF 2 datasets

Motif DE_60h DE_60h-HLF_MA0043.4 9 bp overlap

Motif DE_72h DE_72h-HLF_MA0043.4 9 bp overlap

HNF1A 1 dataset

Motif DE_72h DE_72h-HNF1A_MA0046.3 13 bp overlap

HNF1B 2 datasets

Motif DE_72h DE_72h-HNF1B_MA0153.2 13 bp overlap

ChIP foregut GSE117136.HNF1B.foregut 531 bp overlap

HNRNPH1 1 dataset

ChIP Hep-G2 ENCSR066FXN.HNRNPH1.Hep-G2 87 bp overlap

HOXB8 1 dataset

ChIP PANC-1 GSE119930.HOXB8.PANC-1 144 bp overlap

Hmga1 1 dataset

Motif DE_72h DE_72h-Hmga1_MA2124.1 8 bp overlap

IKZF1 1 dataset

ChIP GM12878 ENCFF753XDO 441 bp overlap

IKZF2 1 dataset

ChIP GM12878 ENCSR680UQE.IKZF2.GM12878 324 bp overlap

IRF4 2 datasets

ChIP GM12878 ENCSR000BGY.IRF4.GM12878 189 bp overlap

ChIP T-cell GSE136853.IRF4.T-cell 293 bp overlap

JUN 1 dataset

ChIP DE_D2 S02-DE-d2-JUN-exp1 286 bp overlap

JUNB 2 datasets

ChIP GM12878 ENCFF667EJQ 346 bp overlap

ChIP GM12878 ENCSR897MMC.JUNB.GM12878 244 bp overlap

KDM1A 1 dataset

ChIP pancreatic-progenitor_GT GSE104840.KDM1A.pancreatic-progenitor_GT 274 bp overlap

Lhx3 1 dataset

Motif DE_72h DE_72h-Lhx3_MA0135.2 12 bp overlap

MEF2B 1 dataset

ChIP GM12878 ENCSR177VFS.MEF2B.GM12878 227 bp overlap

MEIS1 3 datasets

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MLLT1 1 dataset

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 310 bp overlap

MTA2 3 datasets

ChIP GM12878 ENCFF615CWQ 351 bp overlap

ChIP GM12878 ENCSR293QAR.MTA2.GM12878 369 bp overlap

ChIP pre-B-cell GSE107886.MTA2.pre-B-cell 243 bp overlap

Mecom 1 dataset

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NBN 1 dataset

ChIP GM12878 ENCSR278SQL.NBN.GM12878 239 bp overlap

NFATC3 1 dataset

ChIP GM12878 ENCSR437GBJ.NFATC3.GM12878 290 bp overlap

NKX2-2 1 dataset

Motif DE_72h DE_72h-NKX2-2_MA1645.2 8 bp overlap

NR2F1 2 datasets

ChIP GM12878 ENCFF273VKX 247 bp overlap

ChIP GM12878 ENCSR514VYD.NR2F1.GM12878 361 bp overlap

Nr5A2 1 dataset

Motif DE_72h DE_72h-Nr5A2_MA0505.3 9 bp overlap

PAX1 1 dataset

Motif DE_72h DE_72h-PAX1_MA0779.2 16 bp overlap

PAX2 1 dataset

Motif DE_72h DE_72h-PAX2_MA0067.3 16 bp overlap

PAX5 2 datasets

ChIP GM12878 ENCSR000BHD.PAX5.GM12878 106 bp overlap

ChIP GM12878 ENCSR000BHJ.PAX5.GM12878 191 bp overlap

PAX8 1 dataset

Motif DE_72h DE_72h-PAX8_MA2094.1 16 bp overlap

PAX9 1 dataset

Motif DE_72h DE_72h-PAX9_MA0781.2 16 bp overlap

PLAG1 1 dataset

ChIP K-562 GSE111469.PLAG1.K-562 51 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_72h DE_72h-POU2F1SOX2_MA1962.1 17 bp overlap

POU2F2 1 dataset

ChIP pre-B-cell GSE107886.POU2F2.pre-B-cell 247 bp overlap

POU4F1 1 dataset

Motif DE_72h DE_72h-POU4F1_MA0790.2 12 bp overlap

POU4F2 1 dataset

Motif DE_72h DE_72h-POU4F2_MA0683.2 15 bp overlap

POU4F3 1 dataset

Motif DE_72h DE_72h-POU4F3_MA0791.2 12 bp overlap

RBM25 1 dataset

ChIP K-562 ENCSR791OZM.RBM25.K-562 73 bp overlap

RELA 1 dataset

ChIP 786-O GSE109953.RELA.786-O 115 bp overlap

RELB 1 dataset

ChIP GM12878 ENCSR387QUV.RELB.GM12878 169 bp overlap

RNF2 1 dataset

ChIP ME-1_Con GSE128771.RNF2.ME-1_Con 83 bp overlap

RUNX1 1 dataset

ChIP epididymis_HEE GSE109061.RUNX1.epididymis_HEE 288 bp overlap

SAFB 2 datasets

ChIP K562 ENCFF765XSF 62 bp overlap

ChIP K562 ENCFF916WYW 73 bp overlap

SATB1 5 datasets

ChIP MCF-10A GSE123292.SATB1.MCF-10A 174 bp overlap

ChIP MCF-10A_CP GSE123292.SATB1.MCF-10A_CP 148 bp overlap

ChIP MCF-10A_ICRF GSE123292.SATB1.MCF-10A_ICRF 177 bp overlap

ChIP MCF-10A_N-term_CUT1 GSE123292.SATB1.MCF-10A_N-term_CUT1 176 bp overlap

ChIP MCF-10A_dHD GSE123292.SATB1.MCF-10A_dHD 198 bp overlap

SIX2 1 dataset

ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 218 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 597 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 528 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 468 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 529 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 508 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 488 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 552 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 458 bp overlap

SMARCE1 1 dataset

ChIP HMLE-Twist-ER_125nM_4OHT GSE96933.SMARCE1.HMLE-Twist-ER_125nM_4OHT 202 bp overlap

SOX10 2 datasets

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 459 bp overlap

TARDBP 1 dataset

ChIP GM12878 ENCSR412QBS.TARDBP.GM12878 256 bp overlap

TBX21 1 dataset

ChIP GM12878 ENCSR739IHN.TBX21.GM12878 284 bp overlap

TEAD1 2 datasets

Motif DE_60h DE_60h-TEAD1_MA0090.4 9 bp overlap

Motif DE_72h DE_72h-TEAD1_MA0090.4 9 bp overlap

TEAD2 2 datasets

Motif DE_60h DE_60h-TEAD2_MA1121.2 7 bp overlap

Motif DE_72h DE_72h-TEAD2_MA1121.2 7 bp overlap

TEAD3 2 datasets

Motif DE_60h DE_60h-TEAD3_MA0808.1 8 bp overlap

Motif DE_72h DE_72h-TEAD3_MA0808.1 8 bp overlap

TEAD4 2 datasets

Motif DE_60h DE_60h-TEAD4_MA0809.3 8 bp overlap

Motif DE_72h DE_72h-TEAD4_MA0809.3 8 bp overlap

TRIM22 2 datasets

ChIP GM12878 ENCSR637QAM.TRIM22.GM12878 165 bp overlap

ChIP GM12878 ENCSR835XKS.TRIM22.GM12878 197 bp overlap

ZNF217 1 dataset

ChIP GM12878 ENCSR764CZW.ZNF217.GM12878 321 bp overlap

ZNF449 2 datasets

Motif DE_60h DE_60h-ZNF449_MA1656.2 10 bp overlap

Motif DE_72h DE_72h-ZNF449_MA1656.2 10 bp overlap

ZNF667 1 dataset

Motif DE_72h DE_72h-ZNF667_MA1984.2 11 bp overlap

ZNF684 2 datasets

Motif DE_60h DE_60h-ZNF684_MA1600.2 14 bp overlap

Motif DE_72h DE_72h-ZNF684_MA1600.2 14 bp overlap

Zfx 2 datasets

Motif DE_60h DE_60h-Zfx_MA0146.3 10 bp overlap

Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap