GMEB1

glucocorticoid modulatory element binding protein 1 | P96PIF, PIF96

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]

Member of: DE-6 DE-6.16

Biological processes 26 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)Hsp27 protein binding (GO:0051008)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)identical protein binding (GO:0042802)negative regulation of apoptotic process (GO:0043066)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein-macromolecule adaptor activity (GO:0030674)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating GMEB1 0 TFs

Transcription factors with Perturb-seq knockdown data for GMEB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GMEB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GMEB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GMEB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:28,369,387–28,370,499	299.0 kb	Distal (>10kb) Multiome	961
chr1:28,505,412–28,506,885	162.8 kb	Distal (>10kb) Multiome	969
chr1:28,513,136–28,516,505	153.3 kb	Distal (>10kb) Multiome	461
chr1:28,517,302–28,519,364	150.4 kb	Distal (>10kb) Multiome	927
chr1:28,552,370–28,553,806	115.8 kb	Distal (>10kb) Multiome	955
chr1:28,580,985–28,582,501	86.9 kb	Distal (>10kb) Multiome	1080
chr1:28,592,018–28,592,768	76.4 kb	Distal (>10kb) Multiome	394
chr1:28,642,403–28,643,726	25.6 kb	Distal (>10kb) Multiome	980
chr1:28,648,003–28,650,002	19.9 kb	Distal (>10kb) Multiome	1377
chr1:28,667,742–28,669,783	376 bp	At TSS Multiome	804
chr1:28,736,098–28,738,080	67.9 kb	Distal (>10kb) Multiome	1106
chr1:28,811,880–28,812,661	143.5 kb	Distal (>10kb) Multiome	219
chr1:28,881,894–28,882,433	213.5 kb	Distal (>10kb) Multiome	615
chr1:28,886,723–28,888,425	219.4 kb	Distal (>10kb) Multiome	709
chr1:28,913,920–28,915,470	245.7 kb	Distal (>10kb) Multiome	738

Genome Browser

Genomic view of the GMEB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.