chr18 : 47,975,686 – 47,976,326
640 bp 79 TFs 1 linked gene
This 640 bp open chromatin element is linked to SMAD2 and is bound by 79 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
SMAD2 45.2 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr18:47,970,686 – 47,981,326
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
79 transcription factors
Source
Cell type
AR 1 dataset
ChIP MDA-MB-453_FOXA1 ERP003503.AR.MDA-MB-453_FOXA1 220 bp overlap
ARNT 1 dataset
ChIP RCC4 GSE85352.ARNT.RCC4 190 bp overlap
BCL6 2 datasets
Motif DE_72h DE_72h-BCL6_MA0463.3 13 bp overlap
ChIP SU-DHL-4 GSE119038.BCL6.SU-DHL-4 349 bp overlap
BCL6B 1 dataset
Motif DE_72h DE_72h-BCL6B_MA0731.1 17 bp overlap
BRD4 4 datasets
ChIP MV4-11_DMSO GSE71776.BRD4.MV4-11_DMSO 250 bp overlap
ChIP MV4-11_SGC GSE71776.BRD4.MV4-11_SGC 189 bp overlap
ChIP RH4_shCHD4 GSE140115.BRD4.RH4_shCHD4 246 bp overlap
ChIP SEM GSE83671.BRD4.SEM 180 bp overlap
CBFA2T3 1 dataset
ChIP U-937 GSE126953.CBFA2T3.U-937 104 bp overlap
CDK7 1 dataset
ChIP Jurkat_DMSO GSE60027.CDK7.Jurkat_DMSO 176 bp overlap
CEBPA 2 datasets
ChIP Kasumi-1_CEBPA-ER_E2 GSE102697.CEBPA.Kasumi-1_CEBPA-ER_E2 136 bp overlap
ChIP MV4-11 GSE88746.CEBPA.MV4-11 298 bp overlap
CTCF 3 datasets
ChIP THP-1_macrophage_PMA GSE96800.CTCF.THP-1_macrophage_PMA 270 bp overlap
ChIP leukemia GSE142161.CTCF.leukemia 178 bp overlap
ChIP leukemia_CEBPA-24h GSE142161.CTCF.leukemia_CEBPA-24h 233 bp overlap
Cebpa 19 datasets
ChIP BLaER1 ENCFF031ISE 416 bp overlap
ChIP BLaER1 ENCFF093OYK 448 bp overlap
ChIP BLaER1 ENCFF140EYR 437 bp overlap
ChIP BLaER1 ENCFF234NTO 398 bp overlap
ChIP BLaER1 ENCFF250ODG 406 bp overlap
ChIP BLaER1 ENCFF274GAT 345 bp overlap
ChIP BLaER1 ENCFF335XTP 556 bp overlap
ChIP BLaER1 ENCFF341QPD 243 bp overlap
ChIP BLaER1 ENCFF346MCV 337 bp overlap
ChIP BLaER1 ENCFF364PUR 486 bp overlap
ChIP BLaER1 ENCFF399AYC 433 bp overlap
ChIP BLaER1 ENCFF419EBE 484 bp overlap
ChIP BLaER1 ENCFF460KDD 576 bp overlap
ChIP BLaER1 ENCFF508JZF 264 bp overlap
ChIP BLaER1 ENCFF798NMV 395 bp overlap
ChIP BLaER1 ENCFF844FIP 522 bp overlap
ChIP BLaER1 ENCFF858JKM 329 bp overlap
ChIP BLaER1 ENCFF896HSY 286 bp overlap
ChIP BLaER1 ENCFF952XLX 456 bp overlap
EBF1 5 datasets
ChIP GM12878 ENCFF167CZS 321 bp overlap
ChIP GM12878 ENCSR000DZQ.EBF1.GM12878 164 bp overlap
ChIP LCL GSE75503.EBF1.LCL 246 bp overlap
ChIP MUTUL GSE75503.EBF1.MUTUL 370 bp overlap
ChIP NALM-6 GSE126300.EBF1.NALM-6 551 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 178 bp overlap
EP300 1 dataset
ChIP 697 GSE138031.EP300.697 174 bp overlap
ERG 1 dataset
ChIP SEM GSE117864.ERG.SEM 223 bp overlap
ESR1 8 datasets
ChIP MCF-7_D538G GSE148277.ESR1.MCF-7_D538G 221 bp overlap
ChIP MCF-7_D538G_DMSO GSE148277.ESR1.MCF-7_D538G_DMSO 390 bp overlap
ChIP MCF-7_E2_45m GSE67295.ESR1.MCF-7_E2_45m 183 bp overlap
ChIP MCF-7_HC11 GSE102882.ESR1.MCF-7_HC11 280 bp overlap
ChIP MCF-7_PROG GSE68355.ESR1.MCF-7_PROG 217 bp overlap
ChIP MCF-7_R5020 GSE68355.ESR1.MCF-7_R5020 322 bp overlap
ChIP MCF-7_estradiol-DHT_4h GSE99626.ESR1.MCF-7_estradiol-DHT_4h 180 bp overlap
ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.ESR1.MCF-7_parental_4-hydroxytamoxifen 262 bp overlap
ESR1_Y537S 1 dataset
ChIP MCF-7_dox GSE94493.ESR1_Y537S.MCF-7_dox 227 bp overlap
EWSR1-FLI1 1 dataset
Motif DE_72h DE_72h-EWSR1-FLI1_MA0149.1 18 bp overlap
EZH2 1 dataset
ChIP WSU-DLCL2 GSE45982.EZH2.WSU-DLCL2 133 bp overlap
FOXA2 3 datasets
ChIP DE DE-FOXA2-1 600 bp overlap
ChIP DE DE-FOXA2-2 65 bp overlap
ChIP DE DE-FOXA2-2 522 bp overlap
FOXP1 1 dataset
ChIP SU-DHL-6 ERP010999.FOXP1.SU-DHL-6 255 bp overlap
GATA2 2 datasets
Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap
ChIP WA09 GSE105081.GATA2.WA09 163 bp overlap
GATA3 1 dataset
ChIP MCF-7_E2_Dex GSE81510.GATA3.MCF-7_E2_Dex 219 bp overlap
GATA4 7 datasets
ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 175 bp overlap
ChIP DE DE-GATA4-1 556 bp overlap
ChIP DE DE-GATA4-2 606 bp overlap
Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap
ChIP foregut GSE117136.GATA4.foregut 465 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 438 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 232 bp overlap
GATA5 1 dataset
Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap
GATA6 10 datasets
ChIP DE DE-GATA6-1 540 bp overlap
ChIP DE DE-GATA6-2 640 bp overlap
Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 267 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 259 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 568 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 460 bp overlap
ChIP foregut GSE117136.GATA6.foregut 485 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 273 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 291 bp overlap
Gata3 1 dataset
Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap
Gfi1B 1 dataset
Motif DE_72h DE_72h-Gfi1B_MA0483.2 10 bp overlap
HAND2 1 dataset
ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 350 bp overlap
IKZF1 2 datasets
ChIP BCR-ABL1_LAX2 GSE58825.IKZF1.BCR-ABL1_LAX2 303 bp overlap
ChIP pre-B-cell GSE107886.IKZF1.pre-B-cell 500 bp overlap
IKZF2 1 dataset
Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap
IKZF3 1 dataset
ChIP pre-B-cell GSE107886.IKZF3.pre-B-cell 325 bp overlap
ISL1 1 dataset
ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 211 bp overlap
JMJD1C 2 datasets
ChIP HL-60 GSE63484.JMJD1C.HL-60 260 bp overlap
ChIP NB4 GSE63484.JMJD1C.NB4 249 bp overlap
KMT2A 1 dataset
ChIP L826 GSE83671.KMT2A.L826 332 bp overlap
MAX 1 dataset
ChIP P493-6 GSE36354.MAX.P493-6 207 bp overlap
MED 1 dataset
ChIP SEM GSE83671.MED.SEM 300 bp overlap
MED1 1 dataset
ChIP P493-6 GSE36354.MED1.P493-6 168 bp overlap
MEF2B 1 dataset
ChIP DLBCL GSE110682.MEF2B.DLBCL 223 bp overlap
MITF 1 dataset
ChIP melanocyte_BRAFV600E GSE50681.MITF.melanocyte_BRAFV600E 320 bp overlap
MTA2 1 dataset
ChIP pre-B-cell GSE107886.MTA2.pre-B-cell 232 bp overlap
MYB 1 dataset
ChIP SEM GSE117864.MYB.SEM 282 bp overlap
MYC 1 dataset
ChIP P493-6_MST-312 GSE77061.MYC.P493-6_MST-312 260 bp overlap
Mecom 1 dataset
Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap
NFE2 1 dataset
ChIP ProEs GSE59087.NFE2.ProEs 137 bp overlap
NR2F2 1 dataset
ChIP MCF-7 ENCSR000BUY.NR2F2.MCF-7 204 bp overlap
NR3C1 4 datasets
ChIP ALL_DEX GSE109946.NR3C1.ALL_DEX 345 bp overlap
ChIP NALM-6 GSE67046.NR3C1.NALM-6 469 bp overlap
ChIP NALM-6_CASP1 GSE67046.NR3C1.NALM-6_CASP1 343 bp overlap
ChIP SUP-B15_DEX GSE107584.NR3C1.SUP-B15_DEX 361 bp overlap
NR4A1 2 datasets
ChIP Kasumi-1 GSE79491.NR4A1.Kasumi-1 125 bp overlap
ChIP MOLM-14_DHE GSE124963.NR4A1.MOLM-14_DHE 314 bp overlap
PAX5 2 datasets
ChIP NALM-6 GSE115764.PAX5.NALM-6 440 bp overlap
ChIP NALM-6 GSE126300.PAX5.NALM-6 514 bp overlap
PBX1 1 dataset
ChIP RCH-ACV GSE85988.PBX1.RCH-ACV 386 bp overlap
Prdm14 1 dataset
Motif DE_72h DE_72h-Prdm14_MA1998.2 8 bp overlap
RAD21 1 dataset
ChIP THP-1_eGFP-IFNb GSE103477.RAD21.THP-1_eGFP-IFNb 157 bp overlap
RELA 1 dataset
ChIP MCF-7_Veh GSE67295.RELA.MCF-7_Veh 398 bp overlap
RUNX1 4 datasets
ChIP 697 GSE138031.RUNX1.697 279 bp overlap
ChIP BCP-ALL_patient1 GSE109377.RUNX1.BCP-ALL_patient1 387 bp overlap
ChIP NALM-6 GSE126300.RUNX1.NALM-6 640 bp overlap
ChIP NB4 GSE81992.RUNX1.NB4 289 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 211 bp overlap
SMAD2-3 1 dataset
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 531 bp overlap
SMAD2_3 2 datasets
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 475 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 463 bp overlap
SMAD3 1 dataset
ChIP endoderm GSE29422.SMAD3.endoderm 169 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 180 bp overlap
SOX10 1 dataset
Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 414 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 488 bp overlap
SOX4 1 dataset
Motif DE_72h DE_72h-SOX4_MA0867.3 8 bp overlap
SOX8 1 dataset
ChIP RH4_Entinostat-6H GSE116344.SOX8.RH4_Entinostat-6H 217 bp overlap
STAG2 1 dataset
ChIP HL-60 GSE131577.STAG2.HL-60 146 bp overlap
STAT1 1 dataset
Motif DE_72h DE_72h-STAT1_MA0137.4 9 bp overlap
Sox6 1 dataset
Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap
Stat5a::Stat5b 1 dataset
Motif DE_72h DE_72h-Stat5aStat5b_MA0519.2 9 bp overlap
TBX2 2 datasets
ChIP Kelly GSE94822.TBX2.Kelly 207 bp overlap
ChIP SK-N-BE2-C GSE94822.TBX2.SK-N-BE2-C 225 bp overlap
TCF3 2 datasets
ChIP 697_HF GSE138031.TCF3.697_HF 192 bp overlap
ChIP RCH-ACV GSE85988.TCF3.RCH-ACV 411 bp overlap
TFAP2A 2 datasets
ChIP MCF-7_E2 GSE60270.TFAP2A.MCF-7_E2 258 bp overlap
ChIP WA09 GSE105081.TFAP2A.WA09 332 bp overlap
TFAP2C 4 datasets
ChIP MCF-7_ETOH GSE23852.TFAP2C.MCF-7_ETOH 208 bp overlap
ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 410 bp overlap
ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 394 bp overlap
ChIP WA09 GSE105081.TFAP2C.WA09 325 bp overlap
THAP1 1 dataset
Motif DE_72h DE_72h-THAP1_MA0597.3 8 bp overlap
TRIM28 2 datasets
ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 192 bp overlap
ChIP hESC GSE115387.TRIM28.hESC 222 bp overlap
TRPS1 1 dataset
Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap
ZBTB42 1 dataset
ChIP HEK293 GSE76494.ZBTB42.HEK293 148 bp overlap
ZFP36 1 dataset
ChIP K562 ENCFF255RZG 192 bp overlap
ZNF143 1 dataset
ChIP MCF-7 GSE76454.ZNF143.MCF-7 237 bp overlap
ZNF257 1 dataset
Motif DE_72h DE_72h-ZNF257_MA1710.2 10 bp overlap
ZNF430 1 dataset
ChIP HepG2 ENCFF967HQR 327 bp overlap
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