chr12:103,825,918–103,826,568

chr12 : 103,825,918 – 103,826,568

650 bp 82 TFs 6 linked genes

This 650 bp open chromatin element is linked to 6 target genes and is bound by 82 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
NT5DC3		14.9 kb	Distal	Multiome
HSP90B1		104.1 kb	Distal	Multiome
UQCC6		139.4 kb	Distal	Multiome
TDG		139.5 kb	Distal	Multiome
ENSG00000288744		139.6 kb	Distal	Multiome
HCFC2		238.2 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

82 transcription factors

ARNT::HIF1A 2 datasets

Motif DE_48h DE_48h-ARNTHIF1A_MA0259.2 5 bp overlap

Motif DE_60h DE_60h-ARNTHIF1A_MA0259.2 5 bp overlap

Atoh1 1 dataset

Motif DE_48h DE_48h-Atoh1_MA1467.3 7 bp overlap

BHLHE22 2 datasets

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

ChIP HEK293T GSE39579.BRD3.HEK293T 159 bp overlap

CREB3L4 2 datasets

Motif DE_48h DE_48h-CREB3L4_MA1474.2 10 bp overlap

Motif DE_60h DE_60h-CREB3L4_MA1474.2 10 bp overlap

ChIP retina_Hu20 GSE137311.CRX.retina_Hu20 305 bp overlap

ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 427 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 465 bp overlap

CTCF 3 datasets

ChIP retina_Hu22 GSE137311.CTCF.retina_Hu22 301 bp overlap

ChIP retina_Hu25 GSE137311.CTCF.retina_Hu25 396 bp overlap

ChIP retina_Hu6 GSE137311.CTCF.retina_Hu6 375 bp overlap

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

DPRX 2 datasets

Motif DE_48h DE_48h-DPRX_MA1480.2 9 bp overlap

Motif DE_60h DE_60h-DPRX_MA1480.2 9 bp overlap

DUX4 2 datasets

Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap

Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap

ChIP SK-N-MC_SHGFP_96H GSE61944.ELF1.SK-N-MC_SHGFP_96H 110 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 327 bp overlap

ETV5::HOXA2 1 dataset

Motif DE_48h DE_48h-ETV5HOXA2_MA1948.2 12 bp overlap

FIGLA 2 datasets

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 636 bp overlap

ChIP DE DE-FOXA2-2 649 bp overlap

Foxl2 2 datasets

Motif DE_48h DE_48h-Foxl2_MA1607.2 10 bp overlap

Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap

GATA1::TAL1 1 dataset

Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 582 bp overlap

ChIP DE DE-GATA4-2 625 bp overlap

ChIP foregut GSE117136.GATA4.foregut 382 bp overlap

GATA5 1 dataset

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 609 bp overlap

ChIP DE DE-GATA6-2 586 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 525 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 607 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 474 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 573 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 650 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 601 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 605 bp overlap

Motif DE_48h DE_48h-GFI1_MA0038.3 11 bp overlap

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

GSC2 4 datasets

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Gata3 1 dataset

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Gfi1B 1 dataset

Motif DE_48h DE_48h-Gfi1B_MA0483.2 10 bp overlap

HAND2 1 dataset

Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap

Hoxa13 2 datasets

Motif DE_48h DE_48h-Hoxa13_MA0650.4 8 bp overlap

Motif DE_60h DE_60h-Hoxa13_MA0650.4 8 bp overlap

IRF5 2 datasets

Motif DE_48h DE_48h-IRF5_MA1420.1 14 bp overlap

Motif DE_60h DE_60h-IRF5_MA1420.1 14 bp overlap

ISL2 3 datasets

Motif DE_48h DE_48h-ISL2_MA0914.2 6 bp overlap

Motif DE_60h DE_60h-ISL2_MA0914.2 6 bp overlap

Motif DE_72h DE_72h-ISL2_MA0914.2 6 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 302 bp overlap

ChIP A549 ENCFF371EPR 381 bp overlap

ChIP VCaP_DHTTHZ1 GSE125245.MED1.VCaP_DHTTHZ1 159 bp overlap

MEF2D 3 datasets

ChIP retina_Hu13 GSE137311.MEF2D.retina_Hu13 348 bp overlap

ChIP retina_Hu21 GSE137311.MEF2D.retina_Hu21 152 bp overlap

ChIP retina_Hu25 GSE137311.MEF2D.retina_Hu25 300 bp overlap

NEUROD1 2 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 209 bp overlap

Motif DE_48h DE_48h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 1 dataset

Motif DE_48h DE_48h-NEUROG2_MA1642.2 7 bp overlap

NFATC3 3 datasets

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

ChIP retina_Hu13 GSE137311.NRL.retina_Hu13 394 bp overlap

Neurod2 3 datasets

Motif DE_48h DE_48h-Neurod2_MA0668.3 8 bp overlap

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Nfat5 3 datasets

Motif DE_48h DE_48h-Nfat5_MA0606.3 8 bp overlap

Motif DE_60h DE_60h-Nfat5_MA0606.3 8 bp overlap

Motif DE_72h DE_72h-Nfat5_MA0606.3 8 bp overlap

Nfatc1 3 datasets

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

OTX1 4 datasets

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

OTX2 2 datasets

Motif DE_48h DE_48h-OTX2_MA0712.3 7 bp overlap

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 447 bp overlap

Olig2 2 datasets

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

PHOX2B 2 datasets

Motif DE_48h DE_48h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_60h DE_60h-PHOX2B_MA0681.3 12 bp overlap

PITX1 4 datasets

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

PITX2 2 datasets

Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap

Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap

PITX3 4 datasets

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

POLR2A 3 datasets

ChIP esophagus muscularis mucosa ENCFF791ZXN 302 bp overlap

ChIP sigmoid colon ENCFF725QFT 388 bp overlap

ChIP sigmoid colon ENCFF748YVT 504 bp overlap

POU4F1 1 dataset

Motif DE_48h DE_48h-POU4F1_MA0790.2 12 bp overlap

POU4F3 1 dataset

Motif DE_48h DE_48h-POU4F3_MA0791.2 12 bp overlap

PRDM1 1 dataset

Motif DE_48h DE_48h-PRDM1_MA0508.4 7 bp overlap

PRDM9 2 datasets

Motif DE_48h DE_48h-PRDM9_MA1723.2 20 bp overlap

Motif DE_60h DE_60h-PRDM9_MA1723.2 20 bp overlap

RHOXF1 4 datasets

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

ChIP retina_Hu22 GSE137311.RORB.retina_Hu22 356 bp overlap

SATB1 2 datasets

Motif DE_48h DE_48h-SATB1_MA1963.2 7 bp overlap

Motif DE_60h DE_60h-SATB1_MA1963.2 7 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 650 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 650 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 599 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 522 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 589 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 434 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 650 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 625 bp overlap

SMARCA4 2 datasets

ChIP 501-mel_SHCTR GSE61965.SMARCA4.501-mel_SHCTR 57 bp overlap

ChIP 501-mel_SHSOX10 GSE61965.SMARCA4.501-mel_SHSOX10 161 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 243 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 316 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 465 bp overlap

SREBF1 2 datasets

Motif DE_48h DE_48h-SREBF1_MA0829.3 10 bp overlap

Motif DE_60h DE_60h-SREBF1_MA0829.3 10 bp overlap

SREBF2 2 datasets

Motif DE_48h DE_48h-SREBF2_MA0828.3 10 bp overlap

Motif DE_60h DE_60h-SREBF2_MA0828.3 10 bp overlap

Sox17 1 dataset

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

Stat5a::Stat5b 1 dataset

Motif DE_48h DE_48h-Stat5aStat5b_MA0519.2 9 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 188 bp overlap

TFAP4 2 datasets

Motif DE_48h DE_48h-TFAP4_MA0691.1 10 bp overlap

Motif DE_60h DE_60h-TFAP4_MA0691.1 10 bp overlap

THAP1 2 datasets

Motif DE_48h DE_48h-THAP1_MA0597.3 8 bp overlap

Motif DE_60h DE_60h-THAP1_MA0597.3 8 bp overlap

TRPS1 1 dataset

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Tcf12 2 datasets

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Twist2 2 datasets

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap

ZEB1 2 datasets

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

ZFP42 2 datasets

Motif DE_48h DE_48h-ZFP42_MA1651.2 13 bp overlap

Motif DE_60h DE_60h-ZFP42_MA1651.2 13 bp overlap

ZNF184 1 dataset

Motif DE_48h DE_48h-ZNF184_MA2120.1 13 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 417 bp overlap

ZNF354C 2 datasets

Motif DE_48h DE_48h-ZNF354C_MA0130.1 6 bp overlap

Motif DE_60h DE_60h-ZNF354C_MA0130.1 6 bp overlap

ZNF528 1 dataset

Motif DE_48h DE_48h-ZNF528_MA1597.1 17 bp overlap

ZNF675 4 datasets

Motif DE_48h DE_48h-ZNF675_MA1714.2 19 bp overlap

Motif DE_48h DE_48h-ZNF675_MA1714.2 19 bp overlap

Motif DE_60h DE_60h-ZNF675_MA1714.2 19 bp overlap

Motif DE_60h DE_60h-ZNF675_MA1714.2 19 bp overlap

ZNF680 1 dataset

Motif DE_48h DE_48h-ZNF680_MA1729.2 11 bp overlap

ZNF75A 2 datasets

Motif DE_48h DE_48h-ZNF75A_MA2097.1 12 bp overlap

Motif DE_60h DE_60h-ZNF75A_MA2097.1 12 bp overlap