CREB3L4

cAMP responsive element binding protein 3 like 4 | AIbZIP, ATCE1, CREB3, CREB4, hJAL

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Developmental clusters: GC5

Biological processes 20 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating CREB3L4 0 TFs

Transcription factors with Perturb-seq knockdown data for CREB3L4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREB3L4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CREB3L4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREB3L4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:153,670,709–153,671,992	296.7 kb	Distal (>10kb) Multiome	884
chr1:153,697,776–153,698,654	269.5 kb	Distal (>10kb) Multiome	313
chr1:153,727,492–153,728,827	240.0 kb	Distal (>10kb) Multiome	702
chr1:153,736,782–153,737,426	230.8 kb	Distal (>10kb) Multiome	10
chr1:153,745,487–153,745,959	222.2 kb	Distal (>10kb) Multiome	55
chr1:153,774,962–153,776,698	192.7 kb	Distal (>10kb) Multiome	671
chr1:153,783,341–153,784,300	184.2 kb	Distal (>10kb) Multiome	794
chr1:153,922,213–153,923,779	44.8 kb	Distal (>10kb) Multiome	856
chr1:153,945,717–153,947,118	21.2 kb	Distal (>10kb) Multiome	866
chr1:153,957,828–153,959,103	9.2 kb	Proximal (<10kb) Multiome	912
chr1:153,963,107–153,964,407	4.2 kb	Proximal (<10kb) Multiome	798
chr1:153,966,072–153,966,650	1.2 kb	Proximal (<10kb)	97
chr1:153,967,147–153,968,324	249 bp	At TSS Multiome	986
chr1:153,977,057–153,978,034	9.7 kb	Proximal (<10kb) Multiome	853
chr1:153,985,902–153,987,184	18.6 kb	Distal (>10kb) Multiome	572
chr1:153,990,402–153,991,082	22.9 kb	Distal (>10kb) Multiome	950
chr1:154,182,339–154,183,774	215.4 kb	Distal (>10kb) Multiome	934
chr1:154,220,079–154,221,864	252.9 kb	Distal (>10kb) Multiome	1071

Genome Browser

Genomic view of the CREB3L4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.