Predicted to enable 5'-nucleotidase activity. Located in mitochondrion. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NT5DC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NT5DC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NT5DC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:102,956,971–102,959,027 | 883.7 kb | Distal (>10kb) Multiome HiCAR | 373 | |
| chr12:103,494,759–103,496,662 | 345.7 kb | Distal (>10kb) Multiome | 456 | |
| chr12:103,575,140–103,575,992 | 265.7 kb | Distal (>10kb) Multiome | 367 | |
| chr12:103,600,637–103,601,628 | 240.1 kb | Distal (>10kb) Multiome | 92 | |
| chr12:103,632,420–103,633,222 | 208.5 kb | Distal (>10kb) Multiome | 329 | |
| chr12:103,825,918–103,826,568 | 14.9 kb | Distal (>10kb) Multiome | 82 | |
| chr12:103,833,999–103,834,205 | 7.0 kb | Proximal (<10kb) | 45 | |
| chr12:103,840,241–103,842,325 | 117 bp | At TSS Multiome | 911 | |
| chr12:103,928,943–103,931,279 | 89.0 kb | Distal (>10kb) Multiome | 1072 | |
| chr12:103,956,327–103,957,900 | 116.1 kb | Distal (>10kb) Multiome | 1090 | |
| chr12:103,965,409–103,966,472 | 124.7 kb | Distal (>10kb) Multiome | 965 | |
| chr12:104,049,717–104,050,283 | 208.9 kb | Distal (>10kb) Multiome | 295 | |
| chr12:104,063,714–104,065,209 | 223.3 kb | Distal (>10kb) Multiome | 950 | |
| chr12:104,137,119–104,139,117 | 297.0 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the NT5DC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.