chr2 : 230,861,557 – 230,861,927

370 bp 71 TFs 1 linked gene

This 370 bp open chromatin element is linked to ITM2C and is bound by 71 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
ITM2C		3.0 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

71 transcription factors

ASCL1 1 dataset

Motif DE_12h DE_12h-ASCL1_MA1100.3 8 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 370 bp overlap

ATF2 1 dataset

ChIP WA01 ENCSR000BQU.ATF2.WA01 202 bp overlap

Ascl2 1 dataset

Motif DE_12h DE_12h-Ascl2_MA0816.1 10 bp overlap

BCL6 1 dataset

ChIP OCI-Ly1 GSE29282.BCL6.OCI-Ly1 191 bp overlap

BCOR 1 dataset

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 199 bp overlap

BHLHE22 1 dataset

Motif DE_12h DE_12h-BHLHE22_MA1635.2 6 bp overlap

Bhlha15 1 dataset

Motif DE_12h DE_12h-Bhlha15_MA1472.3 8 bp overlap

CDK9 1 dataset

ChIP MM1-S_DMSO GSE42161.CDK9.MM1-S_DMSO 50 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 219 bp overlap

CTCF 1 dataset

ChIP MM1-S GSE43743.CTCF.MM1-S 261 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF274GAT 235 bp overlap

EGR1 1 dataset

ChIP H1 ENCFF451BLH 235 bp overlap

EGR2 1 dataset

ChIP HEK293 ENCFF336LFH 289 bp overlap

ETS1 2 datasets

ChIP CTV-1_DSG_SPI1-mut GSE128835.ETS1.CTV-1_DSG_SPI1-mut 168 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 370 bp overlap

ETV6 1 dataset

ChIP WTC11 ENCFF812SCD 370 bp overlap

EZH2 1 dataset

ChIP Hep-3B2-1-7 GSE128137.EZH2.Hep-3B2-1-7 213 bp overlap

FOXA1 1 dataset

ChIP breast_tumor_Male_14 GSE104399.FOXA1.breast_tumor_Male_14 119 bp overlap

FOXK1 1 dataset

ChIP WTC11 ENCFF875IGU 343 bp overlap

GATA4 1 dataset

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 229 bp overlap

GATA6 1 dataset

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 310 bp overlap

HAND2 1 dataset

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 186 bp overlap

HDAC2 1 dataset

ChIP WA01 ENCSR000AVB.HDAC2.WA01 182 bp overlap

HEY2 1 dataset

ChIP hiPSC GSE81585.HEY2.hiPSC 184 bp overlap

HIF3A 1 dataset

ChIP Hep-3B2-1-7 GSE129491.HIF3A.Hep-3B2-1-7 278 bp overlap

JUN 1 dataset

ChIP HUES-8 GSE109524.JUN.HUES-8 281 bp overlap

KDM5B 1 dataset

ChIP SUM185_SHCTCF GSE46055.KDM5B.SUM185_SHCTCF 139 bp overlap

MYB 1 dataset

ChIP Jurkat GSE59657.MYB.Jurkat 272 bp overlap

MYF5 1 dataset

Motif DE_12h DE_12h-MYF5_MA1641.2 8 bp overlap

MYOD1 3 datasets

Motif DE_12h DE_12h-MYOD1_MA0499.3 9 bp overlap

ChIP IMR-90_GM GSE128527.MYOD1.IMR-90_GM 333 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 155 bp overlap

MYOG 1 dataset

Motif DE_12h DE_12h-MYOG_MA0500.3 8 bp overlap

NELFE 1 dataset

ChIP K-562_NHS GSE112379.NELFE.K-562_NHS 56 bp overlap

NEUROG2 2 datasets

ChIP MRC-5_NFD_02DPT GSE75910.NEUROG2.MRC-5_NFD_02DPT 167 bp overlap

ChIP MRC-5_NFD_1DPT GSE75910.NEUROG2.MRC-5_NFD_1DPT 193 bp overlap

NFYB 1 dataset

ChIP K-562 GSE26439.NFYB.K-562 224 bp overlap

NHLH1 1 dataset

Motif DE_12h DE_12h-NHLH1_MA0048.3 9 bp overlap

NKX2-5 2 datasets

ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 370 bp overlap

ChIP hESC_sc-14033 GSE89457.NKX2-5.hESC_sc-14033 370 bp overlap

Neurod2 1 dataset

Motif DE_12h DE_12h-Neurod2_MA1993.2 6 bp overlap

OSR2 1 dataset

ChIP HEK293 GSE76494.OSR2.HEK293 156 bp overlap

Olig2 1 dataset

Motif DE_12h DE_12h-Olig2_MA1997.2 6 bp overlap

PAX5 1 dataset

ChIP NALM-6 GSE126300.PAX5.NALM-6 105 bp overlap

PKNOX1 3 datasets

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 207 bp overlap

ChIP MCF-7 ENCFF116OCS 370 bp overlap

ChIP MCF-7 ENCSR986XYK.PKNOX1.MCF-7 370 bp overlap

POLR2A 2 datasets

ChIP H1 ENCFF566JSR 351 bp overlap

ChIP H1 ENCFF566JSR 147 bp overlap

POU5F1 3 datasets

ChIP BG03 GSE21614.POU5F1.BG03 172 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 247 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 368 bp overlap

PRDM9 1 dataset

Motif DE_12h DE_12h-PRDM9_MA1723.2 20 bp overlap

Ptf1A 1 dataset

Motif DE_12h DE_12h-Ptf1A_MA1619.2 8 bp overlap

RBBP5 2 datasets

ChIP H1 ENCFF905HFL 370 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 60 bp overlap

REST 4 datasets

ChIP HEK293 ENCFF073DOT 58 bp overlap

ChIP HL-60 ENCFF589LOF 54 bp overlap

ChIP K-562 ENCSR000ATM.REST.K-562 51 bp overlap

ChIP colorectal-cancer_shCDH1 GSE112555.REST.colorectal-cancer_shCDH1 66 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 158 bp overlap

SIX2 3 datasets

ChIP HEK GSE73865.SIX2.HEK 320 bp overlap

ChIP kidney_fetal_16w GSE75948.SIX2.kidney_fetal_16w 224 bp overlap

ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 240 bp overlap

SMARCC1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 200 bp overlap

SP1 3 datasets

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 314 bp overlap

ChIP WTC11 ENCFF688PEU 370 bp overlap

SP2 1 dataset

ChIP HEK293 ENCSR807LQP.SP2.HEK293 218 bp overlap

SP3 1 dataset

ChIP HEK293 ENCSR141PZA.SP3.HEK293 261 bp overlap

SP4 2 datasets

ChIP HEK293 GSE76494.SP4.HEK293 159 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 154 bp overlap

TAF1 2 datasets

ChIP H1 ENCFF478SZO 334 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 288 bp overlap

TBP 3 datasets

ChIP hESC GSE122298.TBP.hESC 191 bp overlap

ChIP hESC_10h GSE122298.TBP.hESC_10h 117 bp overlap

ChIP hESC_8h GSE122298.TBP.hESC_8h 134 bp overlap

TBX5 5 datasets

ChIP G296S GSE85628.TBX5.G296S 370 bp overlap

ChIP G296S_2 GSE85628.TBX5.G296S_2 370 bp overlap

ChIP cardiomyocyte_5 GSE85628.TBX5.cardiomyocyte_5 369 bp overlap

ChIP cardiomyocyte_7 GSE85628.TBX5.cardiomyocyte_7 358 bp overlap

ChIP hiPSC GSE81585.TBX5.hiPSC 332 bp overlap

TCF3 2 datasets

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 294 bp overlap

ChIP RCH-ACV GSE85988.TCF3.RCH-ACV 128 bp overlap

THAP1 1 dataset

Motif DE_12h DE_12h-THAP1_MA0597.3 8 bp overlap

TP53 1 dataset

ChIP hESC_DAMAGED GSE39912.TP53.hESC_DAMAGED 73 bp overlap

Tcf12 1 dataset

Motif DE_12h DE_12h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_12h DE_12h-Twist2_MA0633.3 6 bp overlap

YY1 1 dataset

ChIP WA01 ENCSR000BKD.YY1.WA01 348 bp overlap

ZFHX2 1 dataset

ChIP HEK293 ENCFF167TUA 367 bp overlap

ZFX 1 dataset

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 308 bp overlap

ZNF121 1 dataset

ChIP WTC11 ENCFF291API 211 bp overlap

ZNF283 1 dataset

ChIP HEK293T GSE78099.ZNF283.HEK293T 157 bp overlap

ZNF320 1 dataset

Motif DE_12h DE_12h-ZNF320_MA1976.2 20 bp overlap

ZNF341 1 dataset

ChIP HEK293 ENCSR185FOY.ZNF341.HEK293 308 bp overlap

ZNF487 1 dataset

ChIP HEK293T GSE78099.ZNF487.HEK293T 192 bp overlap

ZNF549 1 dataset

Motif DE_12h DE_12h-ZNF549_MA1728.2 8 bp overlap