Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF487. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF487 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF487, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:43,137,532–43,139,055 | 298.6 kb | Distal (>10kb) Multiome | 754 | |
| chr10:43,202,016–43,204,485 | 234.2 kb | Distal (>10kb) Multiome | 505 | |
| chr10:43,204,643–43,205,459 | 231.9 kb | Distal (>10kb) Multiome | 272 | |
| chr10:43,228,465–43,230,305 | 207.4 kb | Distal (>10kb) Multiome | 290 | |
| chr10:43,265,915–43,267,309 | 170.3 kb | Distal (>10kb) Multiome | 244 | |
| chr10:43,322,425–43,323,518 | 114.1 kb | Distal (>10kb) Multiome | 215 | |
| chr10:43,361,820–43,362,935 | 74.7 kb | Distal (>10kb) Multiome | 416 | |
| chr10:43,395,694–43,397,607 | 41.0 kb | Distal (>10kb) Multiome | 1120 | |
| chr10:43,407,131–43,410,086 | 28.0 kb | Distal (>10kb) Multiome | 1109 | |
| chr10:43,420,185–43,421,230 | 16.4 kb | Distal (>10kb) Multiome | 1071 | |
| chr10:43,436,316–43,437,609 | 155 bp | At TSS Multiome | 970 | |
| chr10:43,455,021–43,456,361 | 18.6 kb | Distal (>10kb) Multiome | 973 | |
| chr10:43,573,680–43,574,942 | 137.4 kb | Distal (>10kb) Multiome | 675 | |
| chr10:43,606,127–43,607,204 | 169.4 kb | Distal (>10kb) Multiome | 620 | |
| chr10:43,648,129–43,649,499 | 211.8 kb | Distal (>10kb) Multiome | 698 | |
| chr10:43,689,359–43,690,800 | 253.1 kb | Distal (>10kb) Multiome | 520 |
Genomic view of the ZNF487 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.