Enables amyloid-beta binding activity. Involved in negative regulation of neuron projection development and neuron differentiation. Located in several cellular components, including Golgi apparatus; lysosome; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ITM2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITM2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITM2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:230,712,242–230,714,378 | 150.9 kb | Distal (>10kb) Multiome | 894 | |
| chr2:230,849,764–230,850,557 | 14.8 kb | Distal (>10kb) Multiome | 238 | |
| chr2:230,861,557–230,861,927 | 3.0 kb | Proximal (<10kb) | 71 | |
| chr2:230,864,158–230,866,508 | 82 bp | At TSS Multiome | 798 | |
| chr2:230,868,036–230,869,662 | 3.1 kb | Proximal (<10kb) | 250 | |
| chr2:230,870,556–230,871,541 | 6.1 kb | Proximal (<10kb) Multiome | 223 | |
| chr2:230,902,219–230,902,930 | 37.7 kb | Distal (>10kb) Multiome | 248 | |
| chr2:230,987,027–230,987,549 | 122.4 kb | Distal (>10kb) Multiome HiCAR | 571 | |
| chr2:231,037,208–231,038,499 | 172.9 kb | Distal (>10kb) Multiome | 457 | |
| chr2:231,052,341–231,053,359 | 188.0 kb | Distal (>10kb) Multiome | 810 | |
| chr2:231,056,470–231,057,439 | 191.8 kb | Distal (>10kb) Multiome | 821 |
Genomic view of the ITM2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.